{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:37Z","timestamp":1787017897267,"version":"build-2736575974"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>BRIT1 (BRCT-repeat inhibitor of hTERT expression), also known as microcephalin (MCPH1), is a crucial gene in the complex cellular machine that is devoted to DNA repair and acts as a regulator of both the intra-S and G2\/M checkpoints. The most important role of BRIT1\/MCPH1 in the regulation of cell cycle progression appears to be the G2\/M checkpoint. The K562 and peripheral blood cells of chronic myeloid leukemia (CML) patients at diagnosis were found to downregulate BRIT1\/MCPH1. However, we could not find any correlation between bcr\/abl activity and the BRIT1\/MCPH1 level. In order to study the genomic instability of CML cells, we evaluated the ability of these cells to arrest mitotic division after exposure to hydroxyurea, a known genotoxic agent. We showed that CML cells continue to proliferate without the activation of the G2\/M cell cycle checkpoint arrest or of the apoptotic mechanism. This behavior may predispose the cells to accumulate genomic defects. In conclusion, we found that CML cells have a low BRIT1\/MCPH1 level and show a defective G2\/M arrest, confirming that these cells have a constitutive genomic instability.<\/jats:p>","DOI":"10.1159\/000329911","type":"journal-article","created":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T08:05:39Z","timestamp":1316160339000},"page":"205-210","source":"Crossref","is-referenced-by-count":26,"title":["BRIT1\/MCPH1 Expression in Chronic Myeloid Leukemia and Its Regulation of the G2\/M Checkpoint"],"prefix":"10.1159","volume":"126","author":[{"given":"C.","family":"Giallongo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Tibullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"La 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