{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:21:19Z","timestamp":1789924879987,"version":"4.0.1"},"reference-count":7,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The contribution of vascular pathology to the rate of progression from mild cognitive impairment (MCI) to Alzheimer\u2019s disease (AD) remains unclear. &lt;i&gt;Objective:&lt;\/i&gt; To ascertain the relative roles of cerebral white matter disease and medial temporal atrophy (MTA) in predicting progression from MCI to AD. &lt;i&gt;Methods:&lt;\/i&gt; MCI patients with baseline MRI and \u226718 months of longitudinal follow-up were evaluated. DSM-IV-TR criteria were used to diagnose conversion to dementia. MTA and white matter hyperintensity (WMH) were quantified using the Scheltens scale and modified Fazekas scale.&lt;i&gt; Results:&lt;\/i&gt; Of a total of 171 MCI patients, 79 patients with baseline MRI and longitudinal follow-up were studied. Twenty-three MCI patients who progressed to dementia (MCI-P) were identified corresponding to a 19.4% annual risk of conversion. In MCI-P patients, the mean Mini-Mental State Examination and Montreal Cognitive Assessment decline was 1.3 and 2.9 points, respectively. MTA, periventricular WMH and deep subcortical WMH were significantly greater in the MCI-P cohort. WMH was found to predict MCI-P with an odds ratio of 7.69 (p = 0.03). &lt;i&gt;Conclusion:&lt;\/i&gt; MTA and deep subcortical WMH independently predict conversion from MCI to AD. Optimization of vascular risk factors among patients with MCI can potentially reduce the conversion from MCI to AD.<\/jats:p>","DOI":"10.1159\/000330019","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T08:15:31Z","timestamp":1310717731000},"page":"431-434","source":"Crossref","is-referenced-by-count":71,"title":["White Matter Disease Independently Predicts Progression from Mild Cognitive Impairment to Alzheimer\u2019s Disease in a Clinic Cohort"],"prefix":"10.1159","volume":"31","author":[{"given":"Kalpana","family":"Prasad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Wiryasaputra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaendran","family":"Kandiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,7,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000101340"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2806%2970355-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2003.019273"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2003.015107"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00868807"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.108.531343"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.0b013e3181b23564"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:25:04Z","timestamp":1745432704000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":7,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,8,1]]},"published-print":{"date-parts":[[2011,8,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000330019","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}