{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:28:53Z","timestamp":1770067733755,"version":"3.49.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Glitazones exhibit beneficial effects in the vascular system, both on large vessels and at a microcirculatory level. We previously reported the effects of glitazones in the aorta of spontaneously hypertensive rats (SHR). We focus now on the acute and long-term actions of these drugs on mesenteric resistance arteries of the SHR. Incubation with pioglitazone or rosiglitazone (10&lt;sup&gt;\u20135&lt;\/sup&gt; mol\/l) improved endothelium-dependent relaxations to acetylcholine and the endothelial modulation of phenylephrine contractions. Acetylcholine relaxations that were abolished by N&lt;sup&gt;G&lt;\/sup&gt;-nitro-&lt;i&gt;L&lt;\/i&gt;-arginine methylester were partly recovered by the glitazones, but no effects of these drugs were observed in the presence of indomethacin or indomethacin + &lt;i&gt;L&lt;\/i&gt;-NAME. Glitazones did not change the contractions to U46619 or the endothelium-independent relaxation to sodium nitroprusside. Three-week oral pioglitazone or rosiglitazone treatment (3 and 10 mg\/kg\/day, respectively) confirmed the acute experiments. Thus, in microvessels, glitazones improve endothelial function in such a way that they do not alter endothelial nitric oxide release but reduce the production of vasoconstrictor prostanoids from endothelial cells.<\/jats:p>","DOI":"10.1159\/000330092","type":"journal-article","created":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T08:34:09Z","timestamp":1313483649000},"page":"72-81","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Pioglitazone and Rosiglitazone on Vascular Function of Mesenteric Resistance Arteries in Rat Genetic Hypertension"],"prefix":"10.1159","volume":"88","author":[{"given":"Yolanda","family":"Mendiz\u00e1bal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00edlvia","family":"Llorens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Nava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,8,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-020963"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjp.0702818"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000177813.99577.6b"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1254%2Fjphs.08117FP"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000044461.01844.C9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.prostaglandins.2004.01.008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.41.1.19"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.107.089680"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.17.9747"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1476-5381.2009.00459.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejphar.2007.08.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2967528-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00508-009-1279-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00004872-198911000-00004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1139%2Fy97-186"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.48.9.1856"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI10506"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.metabol.2009.07.002"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-7061%2899%2900216-2"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:25:59Z","timestamp":1745432759000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":19,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2011,9,1]]},"published-print":{"date-parts":[[2011,9,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000330092","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}