{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:40:07Z","timestamp":1745433607257,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Mitochondrial permeability transition pore (MPTP) opening appears to play a key role in myocardial cell survival after ischemia-reperfusion injury and can be inhibited by cyclosporin A (CsA). We investigated whether low-dose CsA added to histidine-tryptophan-ketoglutarate (HTK) cardioplegia solution could improve myocardial protection during longer periods of global myocardial ischemia as encountered during cardiac surgery. &lt;i&gt;Methods:&lt;\/i&gt; Rabbit hearts perfused on a Langendorff apparatus were arrested with cold HTK solution containing 1 \u00b5mol\/l CsA. After 90 min of ischemia, the hearts were reperfused and pmax, max dp\/dt, min dp\/dt, myocardial stiffness, pO&lt;sub&gt;2&lt;\/sub&gt;, coronary flow and heart rate recorded. Tissue ATP and malondialdehyde (MDA) were measured to assess cell energy content and oxidative stress, respectively. &lt;i&gt;Results:&lt;\/i&gt; CsA-treated hearts recovered pmax (p = 0.026), max dp\/dt (p = 0.028) and min dp\/dt (p = 0.025) more quickly and to a greater extent than non-treated hearts. They required markedly less oxygen (p = 0.041) in the first 10 min of reperfusion. Hearts treated with CsA produced 44% less MDA (1.09 vs. 1.93, p = 0.008), while ATP levels were unchanged. &lt;i&gt;Conclusions:&lt;\/i&gt; HTK cardioplegia solution containing CsA at a dose well below that expected to cause systemic immunosuppressive effects leads to a significant and timelier recovery of myocardial contractility, while consuming less oxygen.<\/jats:p>","DOI":"10.1159\/000330099","type":"journal-article","created":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T10:19:20Z","timestamp":1316600360000},"page":"167-173","source":"Crossref","is-referenced-by-count":9,"title":["Cardioprotective Effects of Low-Dose Cyclosporin A Added to Histidine-Tryptophan-Ketoglutarate Cardioplegia Solution prior to Total Myocardial Ischemia: An in vitro Rabbit Heart Study"],"prefix":"10.1159","volume":"88","author":[{"given":"P.","family":"Pritzwald-Stegmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hoyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kempfert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dhein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.W.","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejcts.2003.12.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2006.12.012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177%2F1089253206291137"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1510%2Ficvts.2008.178343"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000103747"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00762735"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fjmcc.1993.1162"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-6576.2007.01342.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0008-6363%2898%2900064-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1113%2Fjphysiol.2003.034231"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cardiores.2007.04.022"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1124%2Fmol.62.1.22"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00395-007-0675-y"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-4975%2896%2900932-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS1010-7940%2800%2900511-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-1020064"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000008583"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1042%2FBST0380841"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbamcr.2011.01.031"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1152%2Fphysrev.00024.2007"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2174%2F092986711794088407"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0808249105"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.109.906610"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm.2282"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tem.2009.03.007"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.272.8.4680"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.expneurol.2007.09.025"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:26:04Z","timestamp":1745432764000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":27,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000330099","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2011]]}}}