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However, due to the low mitotic activity of the B cells, cytogenetic analyses of B-cell lymphoid proliferations are difficult to perform. In the present study we stimulated canine B-cell lymphoma cells with the immunostimulatory CpG-oligonucleotide DSP30 in combination with interleukin-2 (IL-2) and obtained an adequate number of metaphases. Cytogenetic analyses revealed the loss of one X chromosome as the sole cytogenetic aberration. Chromosome analysis of the corresponding blood showed a normal female karyotype. Monosomy X as the sole clonal chromosomal abnormality is found in human hematopoietic malignancies as well, thus the dog may serve as a promising animal model.<\/jats:p>","DOI":"10.1159\/000330126","type":"journal-article","created":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T11:29:11Z","timestamp":1315826951000},"page":"79-82","source":"Crossref","is-referenced-by-count":2,"title":["Cytogenetic Analysis of CpG-Oligonucleotide DSP30 plus Interleukin-2-Stimulated Canine B-Cell Lymphoma Cells Reveals the Loss of One X Chromosome as the Sole Abnormality"],"prefix":"10.1159","volume":"135","author":[{"given":"N.","family":"Reimann-Berg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Murua Escobar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kiefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mischke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Willenbrock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Eberle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bullerdiek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,7,28]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016%2FS0165-4608%2897%2983556-X"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1007%2Fs10577-007-1212-4"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1006%2Fgeno.1999.5947"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1023%2FA%3A1024133628927"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1016%2FS0301-472X%2800%2900144-2"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1159%2F000200083"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1038%2Fsj.leu.2404935"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1177%2F030098589403100504"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1159%2F000134326"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1159%2F000317077"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1016%2FS0302-2838%2801%2900030-6"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1038%2Fleu.2008.252"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:26:26Z","timestamp":1745432786000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,9,1]]},"published-print":{"date-parts":[[2011,9,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000330126","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"type":"print","value":"1424-8581"},{"type":"electronic","value":"1424-859X"}],"subject":[],"published":{"date-parts":[[2011]]}}}