{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:25:06Z","timestamp":1790717106356,"version":"4.1.0"},"reference-count":10,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lifestyle Genomics"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Coronary artery disease (CAD) is a complex disorder involving genetic and non-genetic factors. Food is an important component of the latter. We examined if DNA polymorphisms in genes encoding enzymes of one-carbon metabolism coupled with low consumption of micronutrients such as folate, vitamins B&lt;sub&gt;6&lt;\/sub&gt; and B&lt;sub&gt;12&lt;\/sub&gt; might increase the risk of CAD. &lt;i&gt;Methods:&lt;\/i&gt; A case-control study consisting of 252 CAD patients and 252 controls were included. Three single nucleotide polymorphisms (SNP), 2 insertion\/deletion and 1 repeat polymorphism were typed. The micronutrient intake was estimated from a standard 24-hour dietary recall coupled to a food frequency questionnaire. &lt;i&gt;Results:&lt;\/i&gt; The results suggest an association of \u2018early-onset CAD\u2019 with betaine homocysteine S-methyl transferase (BHMT) 742G\u2192A SNP (odds ratio = 1.52; 95% confidence interval, 0.96\u20132.41; p = 0.04). No association was observed for all age of onset, but more patients than controls whose micronutrient intake was in the lowest quintile also carried the minor allele (50% patients vs. 37% controls; p = 0.042). Furthermore, dietary intake of folate micronutrients below the recommended daily allowance was observed in a larger percent of patients than controls with the minor BHMT allele (51% patients vs. 44% controls; p = 0.021). &lt;i&gt;Conclusions:&lt;\/i&gt; In the presence of the minor BHMT allele, a decreased consumption of folate micronutrients might increase the risk of CAD.<\/jats:p>","DOI":"10.1159\/000330229","type":"journal-article","created":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T08:29:17Z","timestamp":1314606557000},"page":"203-209","source":"Crossref","is-referenced-by-count":6,"title":["Gene Polymorphisms and Low Dietary Intake of Micronutrients in Coronary Artery Disease"],"prefix":"10.1159","volume":"4","author":[{"given":"Prakruti R.","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita S.","family":"Lele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari S.","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.297.3.286"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.reprotox.2005.03.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fije%2F19.4.899"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0595-111"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejim.2007.02.020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ymgme.2007.02.004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1247%2Fcsf.20.191"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-0004.2002.610212.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2803%2900010-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.06-5734com"}],"container-title":["Lifestyle Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:27:07Z","timestamp":1745432827000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,11,1]]},"published-print":{"date-parts":[[2011,11,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000330229","archive":["Portico"],"relation":{},"ISSN":["2504-3161","2504-3188"],"issn-type":[{"value":"2504-3161","type":"print"},{"value":"2504-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}