{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:52:22Z","timestamp":1761155542011,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T00:00:00Z","timestamp":1315353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T00:00:00Z","timestamp":1315353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Several polymorphisms of vasoactive hormones have been implicated in hypertension. Erythropoietin (EPO) interacts with vasoactive substances, such as angiotensin II. Previously detected single nucleotide polymorphisms in the hypoxia-responsive element of EPO might be associated with hypertension and hypertensive end organ damages. &lt;i&gt;Methods:&lt;\/i&gt; 400 hypertensive patients and 200 age- and gender-matched normotensive controls were genotyped for an EPO polymorphism [cytosine (C)\/thymine (T) single nucleotide polymorphism] at position 3434. Patients were grouped according to their genotype into the CC group (CC genotype) and the CT\/TT group (CT and TT genotype). BP was measured by ambulatory BP monitoring. &lt;i&gt;Results:&lt;\/i&gt; The CC genotype was present in 87% of hypertensive patients and in 78.5% of controls (p = 0.007). In addition, patients with the CC genotype had higher BP levels compared with CT\/TT genotypes (BPsys 143.7 \u00b1 20.4 vs. 136.1 \u00b1 13.5 mm Hg, p = 0.01, and BPdias 85.8 \u00b1 11.6 vs. 82.4 \u00b1 8.9, p = 0.043) despite a nearly identical number of antihypertensive drugs (2.3 \u00b1 1.5 vs. 2.3 \u00b1 1.6; p = 0.257). 100% of the small number of patients with end-stage renal disease (n = 15) had the CC genotype. &lt;i&gt;Conclusion:&lt;\/i&gt; The CC genotype of the EPO gene at position 3434 is more frequently found in patients with hypertension and is associated with higher BP levels.<\/jats:p>","DOI":"10.1159\/000330245","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T08:14:56Z","timestamp":1315383296000},"page":"71-76","source":"Crossref","is-referenced-by-count":4,"title":["An Erythropoietin Gene Polymorphism in the Hypoxia-Responsive Element at Position 3434 Is Possibly Associated with Hypertension"],"prefix":"10.1159","volume":"35","author":[{"given":"E.G.","family":"Schulz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.L.","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Menne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Schettler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mackenbrock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.F.","family":"Popov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.C.","family":"Hagenah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hinz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bargfeldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Haller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,9,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000107251.49515.c2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1385%2FCT%3A5%3A2%3A109"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2899%2970413-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.27.79"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.21.11609"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.24.501"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1139%2Fy03-012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-7061%2899%2900081-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000054227"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00005344-199800001-00132"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1006%2Fbcmd.1997.0134"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.2849206"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0360-3016%2898%2900298-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.051606598"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M314099200"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2486%2Findhealth.37.76"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1006%2Fbmme.1997.2627"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.01-0944rev"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004240100679"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS1079-9796%2803%2900153-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000038731.19106.D1"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2F321674a0"}],"container-title":["Kidney 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