{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:24:34Z","timestamp":1776396274336,"version":"3.51.2"},"reference-count":13,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Objective: To investigate the diagnostic value of the nuclear matrix protein 22 (NMP22) test in comparison to urine cytology for the detection of upper tract urothelial carcinoma. Patients and Methods: Patients with transitional cell carcinoma of the upper urinary tract (n = 34) and patients with renal calculosis (n = 25) were included in this study. Voided urine samples and separated catheter urine specimens were assayed for NMP22 and cytological examination. Results: The sensitivity of the NMP22 test in separated and voided urine was 73.2 and 70.5%, respectively, compared to 64.7 and 58.8% of urine cytology. The specificity of the NMP22 test in separated and voided urine was 88 and 92%, respectively, compared to 96 and 96% of urine cytology. The combination of separated and voided urine is the best method because the sensitivity is 79.41% and specificity 88%. There is a high agreement of the NMP22 test in voided and separated urine (kappa = 0.795, p &lt; 0.01), indicating that the voided urine is adequate for diagnosis. Conclusions: The NMP22 test has higher sensitivity but lower specificity than cytology. The combination of these two tests could be a very useful diagnostic method for detection of upper urothelial tumors.<\/jats:p>","DOI":"10.1159\/000330246","type":"journal-article","created":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T11:29:11Z","timestamp":1315826951000},"page":"134-137","source":"Crossref","is-referenced-by-count":28,"title":["Diagnostic Value of the Nuclear Matrix Protein 22 Test and Urine Cytology in Upper Tract Urothelial Tumors"],"prefix":"10.1159","volume":"87","author":[{"given":"M.","family":"Jovanovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Soldatovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Janjic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vuksanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Dzamic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Acimovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hadzi-Djokic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2802%2902136-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2899%2900383-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2004.04.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2967019-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2005.03.014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000049809"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2966080-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2006.08.001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2800%2900489-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0302-2838%2803%2900147-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2006.04.017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200102000-00081"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.293.7.810"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/uin\/article-pdf\/87\/2\/134\/3904277\/000330246.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/uin\/article-pdf\/87\/2\/134\/3904277\/000330246.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:27:13Z","timestamp":1745432833000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,9,1]]},"published-print":{"date-parts":[[2011,9,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000330246","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}