{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:54:32Z","timestamp":1791273272811,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1159\/000330294","type":"journal-article","created":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T07:22:16Z","timestamp":1315984936000},"page":"434-440","source":"Crossref","is-referenced-by-count":17,"title":["Coordinated Increase in Serum Platelet-Derived Growth Factor-BB and Transforming Growth Factor-\u03b21 in Patients with Chronic Pancreatitis"],"prefix":"10.1016","volume":"11","author":[{"given":"Krystian","family":"Adrych","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Smoczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Stojek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Sledzinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Korczynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Goyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Swierczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1159\/000330294_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH675>3.0.CO;2-N","article-title":"Collagen type I synth esized by pancreaficperiacinar stellate cells (PSC) co localizes with lipid per oxidation-derived aldehydes in chronic alcoholic pancreatitis","volume":"192","author":"Casini","year":"2000","journal-title":"J Pathol"},{"key":"10.1159\/000330294_bib2","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/modpathol.3800613","article-title":"Fibrogenesisin alcoholic chronfepancreatitis: the role of tissue necrosis, macrophages, myofibrobiasts and cytokines","volume":"19","author":"Detlefsen","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1159\/000330294_bib3","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1097\/PAS.0b013e31815d2583","article-title":"Autoimmune pancreatifis: expression and cellular source of profibrotic cytokines and their receptors","volume":"32","author":"Detlefsen","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"10.1159\/000330294_bib4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000105499","article-title":"Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells","volume":"7","author":"Flu","year":"2007","journal-title":"Pancreatology"},{"issue":"suppl 17","key":"10.1159\/000330294_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00535-006-1929-4","article-title":"Can measurement of chemokines become useful biological and functional mark ers of early-stage chronicpancreatitis?","volume":"42","author":"Ito","year":"2007","journal-title":"J Gasnoenterol"},{"key":"10.1159\/000330294_bib6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/01.mpa.0000168222.05591.a0","article-title":"Differential and oynergistic effects o\u00a3 platelet derived growth factor-BB and transforming growth factorbeta] on activated pancreatic stellate cells","volume":"31","author":"Kordes","year":"2005","journal-title":"Pancreas"},{"key":"10.1159\/000330294_bib7","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cgh.2009.07.038","article-title":"Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis","volume":"7","author":"Masamune","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1159\/000330294_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00006676-200104000-00015","article-title":"Effects of syntheticserme protease inhibitors on proliferation and collagen synthesis of human pancreatic periacinar if broblastlikecells","volume":"22","author":"Nakamura","year":"2001","journal-title":"Pancreas"},{"issue":"suppl 1","key":"10.1159\/000330294_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1440-1746.2007.05296.x","article-title":"Pancreatic stellatecells: molecular mechanism of pancreatic fibrosis","volume":"23","author":"Shimizu","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1159\/000330294_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1440-1746.2007.05206.x","article-title":"Pancreatic stellate cells: new target in the treatment of chronic pancreatifis","volume":"23","author":"Talukdar","year":"2008","journal-title":"J Gastroemerol Hepatol"},{"key":"10.1159\/000330294_bib11","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/MPA.0b013e3181967670","article-title":"Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention","volume":"38","author":"Zion","year":"2009","journal-title":"Pancreas"},{"key":"10.1159\/000330294_bib12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen"},{"key":"10.1159\/000330294_bib13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/gut.44.4.534","article-title":"Pancreatic stellate cells are act vated by proinfiammatory cytokines: implicafions\u00a3orpancreaflc\u00a3ibrogenesis","volume":"44","author":"Apte","year":"1999","journal-title":"Gut"},{"key":"10.1159\/000330294_bib14","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/gut.51.4.579","article-title":"Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells","volume":"51","author":"faster","year":"2002","journal-title":"Gut"},{"key":"10.1159\/000330294_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1124\/jpet.102.040287","article-title":"Inhibition of p3S mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells","volume":"304","author":"Masarnmre","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1159\/000330294_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1620\/tjem.199.69","article-title":"Differential roles of signal - ingpathways for proliferation and migration of rat pancreatic Aellate cells","volume":"199","author":"Masamune","year":"2003","journal-title":"Tohoku J Exp Med"},{"key":"10.1159\/000330294_bib17","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.bcp.2003.11.013","article-title":"Pancreatic stellate cell migration: role of the phosphatidyLhiositol 3-kinase(PI3-kinase) pathway","volume":"67","author":"McCarroll","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1159\/000330294_bib18","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/labinvest.3700669","article-title":"Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations","volume":"87","author":"Prud'homme","year":"2007","journal-title":"Lab Invest"},{"key":"10.1159\/000330294_bib19","first-page":"273","article-title":"Mechanisms o\u00a3pancreatic fibrosis","volume":"22","author":"Apte","year":"2004","journal-title":"DigDis"},{"key":"10.1159\/000330294_bib20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/mpa.0b013e318073cf98","article-title":"Expression of transforming growth factor beta by small duct epithelium in chronic, cancer-associated, obstructive pancreatitis: an in situ hybridization study and review of the literature","volume":"35","author":"Fukumura","year":"2007","journal-title":"Pancreas"},{"key":"10.1159\/000330294_bib21","first-page":"42","article-title":"Accumulation of extrac,ehular matrix and developmental dysregulationirrthepancreas bytransgenicproduction of transforming growth factor-beta 1","volume":"147","author":"Lee","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1159\/000330294_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1172\/JCI30082","article-title":"The pancreatic stellate cell a star on the rise in pancreatic diseases","volume":"117","author":"Omary","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1159\/000330294_bib23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/gut.52.2.275","article-title":"Rat pancreatic stellate cells secrete matrix metailoproteinases implications for extra cellular matrix turnover","volume":"52","author":"Phillips","year":"2003","journal-title":"Gut"},{"key":"10.1159\/000330294_bib24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/00006676-199705000-00008","article-title":"Morphological and immunocytochemical identification of periacinar fibroblast like cells derived from human pancrealicacini","volume":"14","author":"Saotorne T Inoue","year":"1997","journal-title":"Pancreas"},{"key":"10.1159\/000330294_bib25","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/S0002-9440(10)61125-X","article-title":"Expression of transforming growth factor-beta 1 bypancreaticstellate cells and its implications for matrix secretion and turnover in chronic pancreatifis","volume":"160","author":"Shek","year":"2002","journal-title":"Ain J Pathol"},{"key":"10.1159\/000330294_bib26","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3748\/wjg.v13.i3.378","article-title":"Effect of emodin on pancreatic fibrosis in rats","volume":"13","author":"Wang","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1159\/000330294_bib27","doi-asserted-by":"crossref","first-page":"6488","DOI":"10.3748\/wjg.14.6488","article-title":"FractaWne and TGF-betal levels reflect the severity of chronic pancreatitis in humans","volume":"14","author":"Yasuda","year":"2008","journal-title":"World J Gastroemerol"},{"key":"10.1159\/000330294_bib28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ijpara.2010.10.007","article-title":"Diagnostic value of non-invasive bio-markers for stage-specific diagnosis of hepatic fibrosis in patients with advanced schismsorniasisjaponica","volume":"41","author":"Hou","year":"2011","journal-title":"Int J Parasitol"},{"key":"10.1159\/000330294_bib29","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3748\/wjg.v9.i11.2490","article-title":"Diagnostic value of platelet derived growth factor- BE, transforming growth factor-betal, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serurn and peripheral blood mononuclear cells for hepatic fibrosis","volume":"9","author":"Zhang","year":"2003","journal-title":"World J Gastroenterol"},{"key":"10.1159\/000330294_bib30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0741-8329(00)00134-8","article-title":"Serum cytokinelevels in alcohol-related liver cirrhosis","volume":"23","author":"Daniluk","year":"2001","journal-title":"Alcohol"},{"key":"10.1159\/000330294_bib31","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1006\/cyto.1999.0660","article-title":"Circulating transforming growth factor beta(1) as an indicator of hepatic function impairment in liver cirrhosis","volume":"12","author":"Fhsiak","year":"2000","journal-title":"Cytokine"},{"key":"10.1159\/000330294_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-8278(99)80001-4","article-title":"Reducedplasma transforming growth factor-beta levels in patients with chronic hepatitis C after interferon-alpha therapy","volume":"30","author":"Tsushima","year":"1999","journal-title":"J Hepatol"},{"key":"10.1159\/000330294_bib33","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1440-1746.2010.06441.x","article-title":"Serum levels of platelet-derived growth factor BB and vascular endothelial growth factor as prognostic factors for patients with fulminant hepatic failure","volume":"26","author":"Takayama","year":"2001","journal-title":"J Gastroenterol Hepaml"},{"key":"10.1159\/000330294_bib34","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/00006676-199804000-00008","article-title":"Criteria for pancreatic disease diagnosis in Japan: diagnostic criteria for chronic pancreatitis","volume":"16","author":"Homma","year":"1998","journal-title":"Pancreas"},{"key":"10.1159\/000330294_bib35","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/gut.25.7.756","article-title":"Classification of parcreatitis","volume":"25","author":"Sarner","year":"1984","journal-title":"Gut"},{"key":"10.1159\/000330294_bib36","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/MEG.0b013e32830cebd7","article-title":"Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis to chronic hepatitis C","volume":"21","author":"Bourster","year":"2009","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1159\/000330294_bib37","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1478-3231.2009.02192.x","article-title":"Validation of FIB-4 and comparison with other simple noninvasive indices for predicting liver fibrosis and cirrhosis to heparitis B virus infected patients","volume":"30","author":"Kim","year":"2010","journal-title":"Liver Int"},{"key":"10.1159\/000330294_bib38","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/jhep.2003.50346","article-title":"A simple noninvasive index can predict both significautfibrosis and cirrhosis in patients with chronic hepatitis C","volume":"38","author":"Wai","year":"2003","journal-title":"Hepatology"},{"key":"10.1159\/000330294_bib39","first-page":"231","article-title":"Parameters of connective tissue metabolism as markers to acute and chronic pancreatitis","volume":"29","author":"Lohr","year":"1991","journal-title":"A yeti ospective study with a cohort of normal subjects (in German). Z Gastroenterol"},{"key":"10.1159\/000330294_bib40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000007588","article-title":"Release of hyaluronan and larninin into pancreatic secretions","volume":"60","author":"Lohr","year":"1999","journal-title":"Digestion"},{"key":"10.1159\/000330294_bib41","first-page":"253","article-title":"Assessment ofthe fibrogenetic activity in chronic pancreatitis","volume":"14","author":"Dominguez-Munoz","year":"1993","journal-title":"The role of circulating levels of extracellular matrix components. Lot J Pancreatol"},{"key":"10.1159\/000330294_bib42","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/hep.20717","article-title":"Comparison and validation of simple noninvasive tests for prediction offibrosis to chi onichepantis C","volume":"41","author":"Lackner","year":"2005","journal-title":"Hepatology"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390311800980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390311800980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T14:19:14Z","timestamp":1712845154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390311800980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S1424390311800980"],"URL":"https:\/\/doi.org\/10.1159\/000330294","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}