{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:40Z","timestamp":1787017900598,"version":"build-2736575974"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Erythroplasia of Queyrat (EQ) is an intra-epithelial carcinoma of the penis. Progression to invasive carcinoma may occur. Its cause is unknown but some evidence suggests infection with human papillomavirus in the pathogenesis of EQ; however, recent data do not confirm this. Therapy is difficult and associated with important recurrence rates. Photodynamic therapy (PDT) employs a photosensitizer excited by visible light. The resulting photodynamic reaction selectively destroys atypical cells. Only few reports exist on the use of topical PDT in the treatment of EQ. &lt;i&gt;Objective:&lt;\/i&gt; We report 11 cases of EQ treated by topical methylaminolaevulinic acid (MAL) PDT. &lt;i&gt;Results:&lt;\/i&gt; Out of 11 male patients withEQ treated by topical MAL-PDT, 3 achieved complete remission sustained for 24 and 51 months and 4 a partial remission sustained for 2\u201345 months with a follow-up period of 4\u201345 months (1 patient lost to follow-up); surprisingly, 2 of the 4 patients with partial remission presented a complete remission after 20 and 45 months of follow-up, respectively, without further therapy. Four patients showed progression of the disease. &lt;i&gt;Conclusion:&lt;\/i&gt; Whereas topical MAL-PDT offers the advantages of tumour specificity, preservation of function and a good cosmetic result, side effects may cause treatment discontinuation in some cases. Treatment of EQ with PDT may represent a valuable option in selected cases, but our data do not allow considering it as a first-line therapeutic option.<\/jats:p>","DOI":"10.1159\/000330328","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T02:46:51Z","timestamp":1313635611000},"page":"52-56","source":"Crossref","is-referenced-by-count":26,"title":["Methylaminolaevulinic Acid Photodynamic Therapy in the Treatment of Erythroplasia of Queyrat"],"prefix":"10.1159","volume":"223","author":[{"given":"Laurence","family":"Feldmeyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Krausz-Enderlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"T\u00f6ndury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Hafner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther F.L.","family":"Hofbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2000.00069.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fsti.2009.039230"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Flsm.1900120303"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.2001.00869.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-0960.2005.00179.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197610%2938%3A4%3C1498%3A%3AAID-CNCR2820380409%3E3.0.CO%3B2-%23"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0366-077X.2003.05635.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2006.07.021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2002.126580"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.28.s1.3.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2893%2992043-S"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1982.tb04562.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.1989.tb00873.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2965650-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-4295%2880%2990078-3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2005.01217.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000249398"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-4295%2880%2990369-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2006.06368.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2002.483111.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2800%2990209-3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F1011-1344%2890%2985083-9"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fbjc.1994.112"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0781.2010.00552.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:28:03Z","timestamp":1745418483000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000330328","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}