{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:57:57Z","timestamp":1762865877338,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T00:00:00Z","timestamp":1323734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T00:00:00Z","timestamp":1323734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2012]]},"abstract":"<i>Objectives:<\/i> The aim of this study was to evaluate the relative risk of identifying fetal chromosomal anomalies after finding ultrasonographic (US) abnormalities in a high-risk population who underwent amniocentesis. <i>Methods:<\/i> A retrospective review of a cohort of patients with single pregnancies who underwent genetic amniocentesis was undertaken. Univariate and multivariate analysis were used to determine the best correlations between US findings and chromosomal abnormalities. <i>Results:<\/i> Overall, 191 chromosomal abnormalities were found in 5,604 fetuses (3.4%). Multivariate analysis showed chromosomal abnormalities were significant ly associated with anomalies of the central nervous system (OR = 4.4, 95% CI 2.2-8.7), face and neck (OR = 15.7, 95% CI 9.2-26.8), heart (OR = 5.4, 95% CI 2.6-11.2), abdomen (OR = 5.6, 95% CI 2.9-10.9), extremities (OR = 5.7, 95% CI 2.4-13.4), an increased nuchal fold (OR = 5.2, 95% CI 3.3-8.1), an intrauterine growth restriction (OR = 3.6, 95% CI 1.6-7.9) and a short femur (OR = 4.1, 95% CI 1.4-12.1). <i>Conclusions:<\/i> Our results confirm the validity of specific US markers in detecting chromosomal abnormalities in the fetus.<\/jats:p>","DOI":"10.1159\/000330373","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T09:48:32Z","timestamp":1323769712000},"page":"55-62","source":"Crossref","is-referenced-by-count":5,"title":["Amniocentesis Performed for Karyotyping after Identified Ultrasonographic Abnormalities: What to Expect?"],"prefix":"10.1159","volume":"31","author":[{"given":"Patrice","family":"Gaudry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Esvan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Baptiste","family":"Meynard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziza","family":"Lebbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Choiset","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Lewin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassili","family":"Tsatsaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Pannier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Grange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2001.115123"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1725"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-4356%2801%2900341-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0258%2819960229%2915%3A4%3C361%3A%3AAID-SIM168%3E3.0.CO%3B2-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2005.07.056"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.a.20359"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1998.12060391.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1162"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.802"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.a.20168"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1979"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-4356%2896%2900002-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000264067"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.225"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000081358"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000224429"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000116744"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330373","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:28:46Z","timestamp":1745432926000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,13]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000330373","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2011,12,13]]}}}