{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:59:40Z","timestamp":1761101980725,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T00:00:00Z","timestamp":1316736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T00:00:00Z","timestamp":1316736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; In very preterm infants, clinical decision-making, such as closing a patent ductus arteriosus (PDA), may be aided by measuring circulating natriuretic and endothelial pro-peptides. &lt;i&gt;Objectives:&lt;\/i&gt; To investigate the association between perinatal characteristics, PDA echocardiography and plasma concentrations of stable pro-peptides of B-type natriuretic peptide (NT-proBNP), atrial natriuretic peptide (MR-proANP) and endothelin-1 (CT-proET-1). &lt;i&gt;Methods:&lt;\/i&gt; A prospective, cross-sectional, single-center study was performed in 66 infants who were less than 32 weeks of gestational age. Pro-peptide concentrations were determined at birth and at day 2\u20133 of life. &lt;i&gt;Results:&lt;\/i&gt; Plasma concentrations of all 3 pro-peptides increased on average 2- to 5-fold from birth to day 2\u20133 of life. NT-proBNP and MR-proANP were closely related at birth and at day 2\u20133 (Rs 0.902 and 0.897, respectively, p &lt; 0.001), whereas CT-proET-1 was related to NT-proBNP and MR-proANP at birth (Rs 0.478 and 0.460, respectively, p &lt; 0.001) but not at day 2\u20133. Birth weight was negatively related to all 3 pro-peptides at birth (p &lt; 0.01); however, preeclampsia and compromised placental perfusion were associated with elevated NT-proBNP and MR-proANP concentrations at birth. At day 2\u20133, MR-proANP and NT-proBNP correlated significantly with the ductal diameter (Rs 0.416 and 0.415, respectively, both p = 0.011), whereas CT-proET-1 correlated with the left atrium\/aorta ratio (Rs 0.506, p = 0.027). CT-proET-1 was elevated in infants with treated compared to untreated PDA [median (5\u201395% range) 388 (272\u2013723) vs. 303 (152\u2013422) pmol\/l, p = 0.011], but not NT-proBNP or MR-proANP. &lt;i&gt;Conclusion:&lt;\/i&gt; CT-proET-1 is a promising predictor in determining the need for PDA intervention.<\/jats:p>","DOI":"10.1159\/000330411","type":"journal-article","created":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T14:54:05Z","timestamp":1316789645000},"page":"116-124","source":"Crossref","is-referenced-by-count":17,"title":["Plasma C-Terminal Pro-Endothelin-1 and the Natriuretic Pro-Peptides NT-proBNP and MR-proANP in Very Preterm Infants with Patent Ductus Arteriosus"],"prefix":"10.1159","volume":"101","author":[{"given":"Julia","family":"Letzner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Schwabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Benzing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils G.","family":"Morgenthaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Ulrich","family":"Bucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"B\u00fchrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romaine","family":"Arlettaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Wellmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2009-3506"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000308367"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000308448"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000315862"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00431-009-0983-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fjp.2010.83"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000283946"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1203%2FPDR.0b013e3181799594"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fjp.2010.47"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080%2F080352501300049406"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1152%2Fphysrev.00032.2009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-005-2022-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2008-1078763"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2005.065581"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinbiochem.2010.12.012"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2010.01861.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2010-1331"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2003.021204"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2010.185967"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fjp.2010.3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.112.4.896"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1330207"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186%2F1741-7015-8-34"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pone.0014506"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:29:06Z","timestamp":1745432946000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,23]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000330411","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2011,9,23]]}}}