{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:05:46Z","timestamp":1785359146371,"version":"3.55.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Like fluoride, lead (Pb) accumulates on the enamel surface pre-eruptively, but it is not yet known whether it also deposits on enamel while dental caries is developing. This study evaluates Pb distribution in bovine enamel slabs submitted to a pH-cycling regimen simulating the caries process. The slabs were subjected to 8 cycles of de- and remineralizing conditions, and Pb (as acetate salt) was added to the de- and remineralized solutions at concentrations of 30 \u00b5g\/l (experimental group, E1) and 300 \u00b5g\/l (experimental group, E2). The control group (C) consisted of solutions to which Pb was not added. After the pH cycling, 100-\u00b5m sections of the slabs were analyzed by polarizing microscopy, to observe the extent of caries-like lesions, and these sections were used for Pb estimation by Synchrotron radiation X-ray microfluorescence. Caries lesions were observed along all superficial enamel surfaces to an extent of 120 \u00b5m. A Pb concentration gradient was observed in enamel, which decreased toward dentine. The highest Pb signals were observed for group E2, and the differences were statistically significant at enamel depths of 0 (C vs. E2; p = 0.029) and 50 \u00b5m (C vs. E2 and E1 vs. E2; p = 0.029). In conclusion, this study suggests that if Pb is present in the oral environment, it may deposit in enamel during the caries process.<\/jats:p>","DOI":"10.1159\/000330602","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T08:14:56Z","timestamp":1315383296000},"page":"469-474","source":"Crossref","is-referenced-by-count":9,"title":["Lead Deposition in Bovine Enamel during a pH-Cycling Regimen Simulating the Caries Process"],"prefix":"10.1159","volume":"45","author":[{"given":"G.F.","family":"Molina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.R.","family":"Costa de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"de Souza Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Cury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.P.","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.","family":"Barroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.F.","family":"Gerlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,9,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1385%2FBTER%3A105%3A1-3%3A159"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00204-006-0096-y"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006%2Fenrs.1998.3880"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177%2F00220345560350031401"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000261373"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0528.1991.tb00122.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080%2F15287399109531472"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0048-9697%2891%2990071-L"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.scitotenv.2008.10.058"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.scitotenv.2011.01.004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.envres.2007.03.007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.scitotenv.2009.12.034"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000016629"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02957016"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.envres.2008.01.002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.apradiso.2009.08.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.scitotenv.2003.08.013"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0048-9697%2886%2990124-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177%2F10454411980090020101"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9969%2873%2990090-3"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:31:00Z","timestamp":1745433060000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,11,1]]},"published-print":{"date-parts":[[2011,11,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000330602","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}