{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:09:21Z","timestamp":1791144561860,"version":"4.1.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; To review the main results of intervention trials which showed the efficacy of periconceptional folic acid-containing multivitamin and folic acid supplementation in the prevention of neural-tube defects (NTD). &lt;i&gt;Methods and Results:&lt;\/i&gt; The main findings of 5 intervention trials are known: (i) the efficacy of a multivitamin containing 0.36 mg folic acid in a UK nonrandomized controlled trial resulted in an 83\u201391% reduction in NTD recurrence, while the results of the Hungarian (ii) randomized controlled trial and (iii) cohort-controlled trial using a multivitamin containing 0.8 mg folic acid showed 93 and 89% reductions in the first occurrence of NTD, respectively. On the other hand, (iv) another multicenter randomized controlled trial proved a 71% efficacy of 4 mg folic acid in the reduction of recurrent NTD, while (v) a public health-oriented Chinese-US trial showed a 41\u201379% reduction in the first occurrence of NTD depending on the incidence of NTD. &lt;i&gt;Conclusions:&lt;\/i&gt; Translational application of these findings could result in a breakthrough in the primary prevention of NTD, but so far this is not widely applied in practice. The benefits and drawbacks of 4 main possible uses of periconceptional folic acid\/multivitamin supplementation, i.e. (i) dietary intake, (ii) periconceptional supplementation, (iii) flour fortification, and (iv) the recent attempt for the use of combination of oral contraceptives with 6S-5-methytetrahydrofolate (methylfolate), are discussed. Obviously, prevention of NTD is much better than the frequent elective termination of pregnancies after prenatal diagnosis of NTD fetuses.<\/jats:p>","DOI":"10.1159\/000330776","type":"journal-article","created":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T02:22:40Z","timestamp":1314238960000},"page":"263-271","source":"Crossref","is-referenced-by-count":71,"title":["Prevention of Neural-Tube Defects with Periconceptional Folic Acid, Methylfolate, or Multivitamins?"],"prefix":"10.1159","volume":"58","author":[{"given":"Andrew E.","family":"Czeizel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Dud\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Paput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"B\u00e1nhidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2889%2992103-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2890%2990060-I"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2891%2990133-A"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0301-2115%2898%2900246-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199212243272602"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fbdra.20086"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199911113412001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.1.3676.1059"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2001.02822.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.40.8.619"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2991205-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.reprotox.2005.03.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2893%2990007-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.274.21.1698"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1024%2F0300-9831.79.2.61"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1476-5381.2009.00492.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2165%2F11532990-000000000-00000"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Ftera.10060"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2105%2FAJPH.2004.058859"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa067103"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2801%2907104-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2Ftera.10079"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2307%2F2135737"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2898%2970047-X"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2FAOG.0b013e3181b46f54"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097%2F01.AOG.0000100153.24061.45"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2004.02.018"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:32:49Z","timestamp":1745418769000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000330776","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}