{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:34:37Z","timestamp":1745469277991,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To investigate the single nucleotide polymorphism 12 (SNP12) in the estrogen receptor \u03b1 (&lt;i&gt;ESR1&lt;\/i&gt;) gene in hypospadiac or cryptorchid patients from Northwestern China. &lt;i&gt;Methods:&lt;\/i&gt; 103 patients and 40 controls were analyzed for SNP12 to verify whether this genetic variant was associated with hypospadias or cryptorchidism. &lt;i&gt;Results:&lt;\/i&gt; The frequencies of the A allele and homozygote individuals for the A allele of SNP12 in the hypospadiac group were higher than in the control group, respectively (p = 0.011, p = 0.005). The frequency of the A allele of SNP12 in the cryptorchid group was higher than in the control group (p = 0.038). However, no significant difference was observed between the cryptorchid group and control group of homozygote individuals for the A allele of SNP12 (p = 0.070). &lt;i&gt;Conclusions:&lt;\/i&gt; Our results suggested that the A allele of SNP12 may increase the risk of hypospadias or cryptorchidism.<\/jats:p>","DOI":"10.1159\/000330902","type":"journal-article","created":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T08:19:25Z","timestamp":1319185165000},"page":"359-362","source":"Crossref","is-referenced-by-count":7,"title":["Molecular Analysis of SNP12 in Estrogen Receptor \u03b1 Gene in Hypospadiac or Cryptorchid Patients from Northwestern China"],"prefix":"10.1159","volume":"87","author":[{"given":"Kai-Fa","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Zhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Ping","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2009.03545.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1986.tb14935.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000112608"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.18.2.259"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumupd%2Fdmm027"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2893%2990953-E"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.reprotox.2004.12.015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2605.2003.00367.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fden098"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177%2F002215540405200306"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-0211"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fbdra.20458"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdel391"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2307%2F2533494"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2F978-1-4419-8995-6_13"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdel513"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:34:11Z","timestamp":1745433251000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000330902","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2011]]}}}