{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:26:20Z","timestamp":1764645980628,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Contrast medium administration during imaging and therapeutic procedures can cause renal injury, partly due to ischemia. Therefore, we hypothesized that brief ischemia and reperfusion episodes applied at a distant site \u2013 multiple balloon inflations and deflations during angioplasty \u2013 may serve as a remote-conditioning (RC) stimulus and thereby protect against contrast-induced kidney injury. To test this hypothesis, we (1) utilized cases from a prior study in which patients undergoing emergent angioplasty for ST segment elevation myocardial infarction received either 1\u20133 balloon inflations (controls) or were \u2018conditioned\u2019 with multiple (\u22674) inflations, and (2) assessed renal function for 3 days in patients with an estimated glomerular filtration rate (eGFR) of &lt;90 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt; prior to revascularization (mild kidney disease). Both groups displayed increased eGFR at day 1 after angioplasty versus baseline; attributed to in-hospital hydration (control: 77 \u00b1 14 vs. 68 \u00b1 12 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt;; p &lt; 0.01; RC: 81 \u00b1 21 vs. 69 \u00b1 12 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt;; p &lt; 0.01). In controls, this improvement was transient: eGFR subsequently decreased to 70 \u00b1 14 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt; at day 3 (p &lt; 0.05). In contrast, the RC group (despite receiving 25% more contrast volume) showed no functional decline at day 3 (80 \u00b1 14 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt;). These results are consistent with remote ischemic conditioning providing a novel potential approach to attenuate contrast-associated renal injury.<\/jats:p>","DOI":"10.1159\/000330930","type":"journal-article","created":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T14:54:05Z","timestamp":1316789645000},"page":"145-150","source":"Crossref","is-referenced-by-count":19,"title":["Remote-Conditioning Ischemia Provides a Potential Approach to Mitigate Contrast Medium-Induced Reduction in Kidney Function: A Retrospective Observational Cohort Study"],"prefix":"10.1159","volume":"119","author":[{"given":"Peter","family":"Whittaker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Przyklenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3109%2F08860229909066978"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pmed.0050137"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00788673"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.87.3.893"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00395-007-0643-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2889%2990437-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080%2F02841850802050762"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2009.08.091"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2Fcirculationaha.106.679167"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1583%2F09-2817.1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2010.07.014"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00395-010-0104-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177%2F1538574410370788"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00330-005-0081-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bcmd.2008.10.014"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1538-7836.2006.02228.x"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330930","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330930","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:34:22Z","timestamp":1745433262000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000330930","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2011]]}}}