{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:34:42Z","timestamp":1745469282580,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; It has been reported that the low level of consistency of diagnosis of atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H) in uterine cervical cancer screening using the Bethesda System, indicating the necessity of a large-scale survey. We presented cases cytologically judged as ASC-H on our website and invited our members to give their opinions regarding the diagnosis by voting online. The Web voting results were analyzed and ASC-H was cytologically investigated. &lt;i&gt;Study Design:&lt;\/i&gt; Virtual slides of atypical cells in cytology preparations of 53 cases were prepared and presented on a website. ASC-H cases were divided into 42 cases sampled by brush scraping and 11 cases sampled by cotton swab scraping. Fifty-three cases cytologically judged as ASC-H were classified into benign and CIN2\/3, and their patterns of arrangement of atypical cells and 8 cytological parameters were morphologically investigated. &lt;i&gt;Results:&lt;\/i&gt; The frequency of ASC-H diagnosis in the Web votes was low: 29.2% for brush-scraped and 26.2% for cotton swab-scraped cases. Three-dimensionality, coarse chromatin and irregular nuclei were significantly different between high-grade squamous intraepithelial lesions and benign cases. &lt;i&gt;Conclusion:&lt;\/i&gt; Web-based surveys showed the difference of cytological findings between high-grade squamous intraepithelial lesions and benign cases. To increase interobserver consistency, it may be useful to share information online, which avoids geographical and temporal limitations.<\/jats:p>","DOI":"10.1159\/000331053","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T18:36:56Z","timestamp":1325875016000},"page":"47-54","source":"Crossref","is-referenced-by-count":2,"title":["World Wide Web-Based Cytological Analysis of Atypical Squamous Cells Cannot Exclude High-Grade Intraepithelial Lesions"],"prefix":"10.1159","volume":"56","author":[{"given":"Kiyotada","family":"Washiya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Takamizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukie","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Himeji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneo","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,1,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000326933"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.22423"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5795%2Fjjscc.46.211"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.23949"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1309%2FXVB01JQYQNM7MJXU"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/331053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/331053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:35:38Z","timestamp":1745433338000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000331053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,1,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000331053","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2012]]}}}