{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:35:20Z","timestamp":1765294520649,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The extracellular protein fetuin-A is a potent soluble inhibitor of calcification, and its deficiency has been associated with vascular calcification in dialysis patients. In proteinuric patients, significant urinary losses of fetuin-A may cause low serum fetuin-A levels. &lt;i&gt;Methods:&lt;\/i&gt; In a cross-sectional study, urinary\/serum concentrations of fetuin-A were investigated in proteinuric children with glomerular diseases and preserved renal function (n = 58) in comparison to healthy controls (n = 246). &lt;i&gt;Results:&lt;\/i&gt; Mean fetuin-A serum concentrations were clearly reduced in children with nephrotic syndrome (0.25 \u00b1 0.14 g\/l, p &lt; 0.001), slightly reduced in children with large proteinuria (0.39 \u00b1 0.15 g\/l, p &lt; 0.05), and comparable to controls in those with mild proteinuria (0.45 \u00b1 0.14 vs. 0.46 \u00b1 0.12 g\/l). Fetuin-A was positively correlated with serum protein (r = 0.58), albumin (r = 0.57), and calcium (r = 0.64), but negatively correlated with proteinuria (r = \u20130.41), albuminuria (r = \u20130.46), and urinary fetuin-A excretion (r = \u20130.48; each p &lt; 0.001). The fractional excretion of fetuin-A was significantly associated with the degree of proteinuria and serum fetuin-A levels. However, the urinary loss of fetuin-A and albumin in nephrotic children differed by three orders of magnitude and the mean fractional excretion of fetuin-A was only 1\/10 of that of albumin (0.016 \u00b1 0.029 vs. 0.162 \u00b1 0.403%; p &lt; 0.001). &lt;i&gt;Conclusions:&lt;\/i&gt; Fetuin-A is clearly reduced in children with nephrotic syndrome and associated with the degree of hypoalbuminemia. This is due to urinary fetuin-A loss and\/or reduced hepatic synthesis. Persistent fetuin-A deficiency may have an impact on cardiovascular morbidity in nephrotic children.<\/jats:p>","DOI":"10.1159\/000331061","type":"journal-article","created":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T07:32:51Z","timestamp":1314948771000},"page":"373-380","source":"Crossref","is-referenced-by-count":7,"title":["Reduced Serum Fetuin-A in Nephrotic Children: A Consequence of 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