{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:39:16Z","timestamp":1791031156644,"version":"4.1.0"},"reference-count":8,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Some studies have implicated the role of apolipoprotein J [clusterin (CLU), apoJ] in the pathogenesis of Alzheimer\u2019s disease (AD). In this study, we investigated the polymorphisms rs11136000 and rs9331888 within CLU in late-onset sporadic AD (LOAD) patients and nondemented subjects. &lt;i&gt;Methods:&lt;\/i&gt; LOAD patients and control subjects were analyzed. Genotyping of rs11136000 and rs9331888 was performed using standard PCR following different restriction endonuclease digestion. &lt;i&gt;Results:&lt;\/i&gt; Although there were no significant differences in genotype frequencies of these two polymorphisms, the haplotype CG was associated with a statistically significantly increased LOAD risk. &lt;i&gt;Conclusion:&lt;\/i&gt; The rs11136000 and rs9331888 polymorphisms of the CLU gene are associated with LOAD.<\/jats:p>","DOI":"10.1159\/000331276","type":"journal-article","created":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T10:12:22Z","timestamp":1322475142000},"page":"198-201","source":"Crossref","is-referenced-by-count":26,"title":["Association of Clusterin Gene Polymorphisms with Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"32","author":[{"given":"Huiying","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Dodel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Farlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansheng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0896-6273%2890%2990342-D"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0029%2820000815%2950%3A4%3C305%3A%3AAID-JEMT10%3E3.0.CO%3B2-L"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneurol.2010.201"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fng.439"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fng.440"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cca.2010.06.013"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1134%2FS0026893310040072"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.63.2.168"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/331276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/331276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:37:54Z","timestamp":1745433474000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000331276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000331276","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}