{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:46:45Z","timestamp":1767926805615,"version":"3.49.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:00:00Z","timestamp":1323820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:00:00Z","timestamp":1323820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Objective: To analyze mid-term neurodevelopment outcome in children with isolated mild ventriculomegaly (VM) \u226412 mm diagnosed in fetal life, using the Battelle Developmental Inventory Screening Test (BDIST). Methods: 86 cases of mild VM were identified. 68 were excluded due to: other cerebral anomalies (n = 40), extra-cerebral anomalies (n = 3), chromosomal defects (n = 4), dysmorphic syndromes (n = 4), congenital infections (n = 2), termination of pregnancy (n = 9), stillbirth (n = 2) and incomplete follow-up (n = 4). 18 cases (range 1-8 years) of isolated mild VM were included for analysis. Seven neurodevelopment domains were assessed by BDIST. Results: Routine neuropediatrical evaluation detected neurological disorders in five children (28%; 3 with language impairment, one left hemiparesis and one intellectual retardation). BDIST showed some degree of neurodevelopmental delay in higher proportions: 66% in social-personal skills, 56% in gross motor skills, 39% in adaptive behavior and 28% in fine motor skills. Communicative and cognitive areas were the least affected (11 and 22% had moderate-to-severe involvement, respectively). A general trend towards worse outcomes was observed in the group of \u22674 years, although significant differences were only found for gross motor skills. Conclusion: Subtle neurological delays may appear during the infant period in fetuses prenatally diagnosed of isolated mild VM. In consequence, adequate measures should be established for early detection and treatment.<\/jats:p>","DOI":"10.1159\/000331408","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T08:37:37Z","timestamp":1323851857000},"page":"12-18","source":"Crossref","is-referenced-by-count":18,"title":["Mid-Term Neurodevelopmental Outcome in Isolated Mild Ventriculomegaly Diagnosed in Fetal Life"],"prefix":"10.1159","volume":"31","author":[{"given":"Paula","family":"G\u00f3mez-Arriaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Herraiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Manuel","family":"Puente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Zamora-Crespo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi","family":"N\u00fa\u00f1ez-Enamorado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Galindo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.310"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1993.03020089.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.138"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.1857"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080%2F714052753"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.941"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.7307"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00247-007-0582-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2898%2980003-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2007.134312"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.2195"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.3909"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.4026"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1999.14050320.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-0466"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177%2F000992289303200504"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.7554"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2897%2900112-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-0528.2007.01301.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.285.18.2339"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2009-0333"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12529-010-9112-y"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093%2Fjpepsy%2Fjsm054"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186%2F1824-7288-36-64"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000151672"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/31\/1\/12\/3892776\/000331408.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/31\/1\/12\/3892776\/000331408.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:39:23Z","timestamp":1745433563000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000331408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,14]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000331408","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,14]]}}}