{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:31:57Z","timestamp":1770881517512,"version":"3.50.1"},"reference-count":9,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; We validated a new method of identifying patients with incident myasthenia in automated Danish registers for the purpose of conducting epidemiological studies of the disorder. &lt;i&gt;Methods:&lt;\/i&gt; For residents of a Danish county (population 484,862) in 1993\u20132008, we identified any hospital contacts coded for myasthenia in a nationwide patient register and any prescriptions for pyridostigmine in the county prescription register. Results from an acetylcholine receptor antibody register were linked to the data. We verified the diagnosis by a review of medical records. &lt;i&gt;Results:&lt;\/i&gt; Subjects identified in the Patient Register (n = 83) were comparable with individuals found in the Prescription Register (n = 89) with regard to age and gender, but were more often seropositive (83.1 vs. 74.2%). Seropositivity increased to 91.6% by restricting the data to individuals recorded in both Patient and Prescription Registers (n = 71). We found that for subjects identified in both Patient and Prescription Registers the positive predictive value of the register diagnosis was 92.9% (95% confidence interval, CI, 84.3\u201397.7), the false-positive rate was low (2.8%), and the sensitivity was acceptable (81.2%; 95% CI 71.2\u201388.8). &lt;i&gt;Conclusions:&lt;\/i&gt; Our data indicate that this novel approach of combining diagnosis register and prescription register information provides a feasible and valid method to trace incident myasthenia patients for population-based epidemiological studies.<\/jats:p>","DOI":"10.1159\/000331481","type":"journal-article","created":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T15:26:26Z","timestamp":1318260386000},"page":"120-128","source":"Crossref","is-referenced-by-count":17,"title":["Identifying Patients with Myasthenia for Epidemiological Research by Linkage of Automated Registers"],"prefix":"10.1159","volume":"37","author":[{"given":"Emil Greve","family":"Pedersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Hallas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poul Erik Hyldgaard","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gaist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2809%2970063-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2007.118950"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.0b013e3181a41211"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000311012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2010.03089.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.287.5462.2398"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fclin.1995.1042"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fije%2F25.2.435"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fmus.20950"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/331481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/331481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:40:08Z","timestamp":1745433608000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000331481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000331481","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}