{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:50:37Z","timestamp":1788929437694,"version":"build-2803163510"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T00:00:00Z","timestamp":1322092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T00:00:00Z","timestamp":1322092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; There are only few studies documenting the long-term outcome of aorto-caval fistula (ACF) in rats, a model of volume overload heart failure (HF). The aim of the present study was to describe HF-related morbidity and mortality, and to examine the relation between cardiac hypertrophy and survival. &lt;i&gt;Methods:&lt;\/i&gt; Adult male Wistar rats underwent needle ACF or sham operation and 71 animals surviving the acute procedure with patent ACF were followed for 52 weeks. &lt;i&gt;Results:&lt;\/i&gt; By the end of the study, 72% of the ACF animals deceased and 82% developed HF signs. Of the HF rats, 65% died (median: 3 weeks after HF onset). Before death, body weight increased by 9% followed by a final drop. 28% ACF rats died suddenly, without preceding HF. Sudden death occurred earlier and in the rats with a trend to larger hearts (p = 0.07). In the whole ACF cohort, heart weight (heart weight\/body weight ratio) was inversely associated with the length of survival (r = \u20130.51, p &lt; 0.001). &lt;i&gt;Conclusion:&lt;\/i&gt; The median survival of ACF Wistar rats is 43 weeks, longer than reported in other rat strains. Increased heart weight is associated with higher mortality and a significant number of animals die suddenly.<\/jats:p>","DOI":"10.1159\/000331562","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T07:42:33Z","timestamp":1322120553000},"page":"167-173","source":"Crossref","is-referenced-by-count":39,"title":["The Course of Heart Failure Development and Mortality in Rats with Volume Overload due to Aorto-Caval Fistula"],"prefix":"10.1159","volume":"35","author":[{"given":"Vojtech","family":"Melenovsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Skaroupkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Benes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Torresova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libor","family":"Kopkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludek","family":"Cervenka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fcvr%2F24.5.430"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yjmcc.2005.02.012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.110.943431"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.72.2.406"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0008-6363%2801%2900245-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpheart.00526.2005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.107.107078"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2F978-1-4615-1893-8_24"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11010-009-0361-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2899%2900474-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Far.21280"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2806%2968074-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199005313222203"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003950050111"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1054%2Fjcaf.2002.32195"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000136815.73623.BE"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11897-010-0031-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11010-011-0808-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1042%2FCS20100527"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehn309"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/331562","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/331562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:41:28Z","timestamp":1745433688000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000331562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,24]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,4,1]]},"published-print":{"date-parts":[[2012,4,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000331562","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,24]]}}}