{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:07Z","timestamp":1745469307001,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objectives:<\/i> To assess the effects of a 4-week levofloxacin course on PSA in asymptomatic men with elevated prostate-specific antigen (PSA) and on prostate biopsy decision. <i>Methods:<\/i> Fifty asymptomatic men with elevated PSA (4.0\u201310.0 ng\/dl) were given levofloxacin 500 mg\/day for 4 weeks followed by repeat PSA. Prostate biopsy was recommended at the end of the study. We compared pre- and post-treatment PSA as well as PSA changes between prostate cancer cases and non-cancer patients. <i>Results:<\/i> Mean (\u00b1SD) PSA decreased from 6.91 \u00b1 2.13 to 6.05 \u00b1 3.0 ng\/dl after antimicrobial treatment (p = 0.025). Twenty-five (56.8%) patients had a post-treatment decrease in PSA, including 20 (45.5%) patients to <4.0 ng\/dl and\/or >25% of the initial PSA value. The difference in PSA change between prostate cancer and non-cancer patients was not statistically significant (p = 0.104). <i>Conclusions:<\/i> Levofloxacin resulted in an overall decrease in PSA for asymptomatic men with PSA in the 4\u201310 ng\/dl range. PSA changes, however, were not significantly different between patients with prostate cancer and non-cancer patients. Prostate cancer was detected in 20% of patients with a clinically relevant PSA decline.<\/jats:p>","DOI":"10.1159\/000331706","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T14:27:13Z","timestamp":1320157633000},"page":"416-419","source":"Crossref","is-referenced-by-count":2,"title":["Antimicrobial Therapy for Asymptomatic Patients with Elevated Prostate-Specific Antigen: Can the Change in Prostate-Specific Antigen Reliably Guide Prostate Biopsy Decisions?"],"prefix":"10.1159","volume":"87","author":[{"given":"Mohammed","family":"Torky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Mosharafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Emran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Abdelhamid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,9,21]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016%2FS0022-5347%2805%2963959-6"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016%2Fj.eururo.2004.08.003"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1097%2F00005392-200011000-00021"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1038%2Fsj.pcan.4500885"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1159%2F000052500"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1159%2F000112612"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016%2Fj.juro.2009.11.044"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1590%2FS1677-55382009000500006"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016%2Fj.juro.2008.09.020"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1097%2F00005392-199706000-00044"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1016%2FS0090-4295%2899%2980383-5"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016%2Fj.juro.2009.07.093"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1038%2Fsj.pcan.4500996"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1097%2F01.ju.0000162017.24965.2b"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1146%2Fannurev.med.57.011205.135654"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1016%2Fj.juro.2009.11.043"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1016%2Fj.juro.2007.10.071"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1007%2Fs10156-007-0570-3"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/331706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/331706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:42:49Z","timestamp":1745433769000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000331706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000331706","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2011]]}}}