{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:27Z","timestamp":1745469327609,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; To evaluate the feasibility of biweekly paclitaxel treatment as maintenance chemotherapy for patients with advanced m\u00fcllerian carcinoma. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Thirty patients with stage III or IV ovarian, fallopian tube, and peritoneal cancers who underwent primary optimal surgery and standard 6 cycles of carboplatin\/taxane-based chemotherapy and exhibited a complete clinical response were entered in this study. Paclitaxel 80 mg\/m&lt;sup&gt;2&lt;\/sup&gt; was administered biweekly for 12 cycles. Patients were evaluated monthly for treatment-related toxicity. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Four patients, including 3 disease progressions and 1 bone marrow suppression, came off the protocol therapy. Twenty-six (86.7%) patients received complete treatment. Although the major toxicity was neutropenia, most of those patients (27\/30, 90.0%) did not experience grade 3 or 4 neutropenia. Twenty-four (80.0%) patients showed persistent grade 1 neuropathy and the remaining 6 (20.0%) did not as a result of prior therapy. However, none experienced neuropathy progression during or after the protocol therapy. Most (17\/22, 77.3%) of the completely treated patients experienced a regression of symptoms during and after therapy. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Biweekly paclitaxel therapy is well tolerated by patients with advanced m\u00fcllerian carcinoma and is therefore acceptable as a candidate for maintenance chemotherapy in these patients.<\/jats:p>","DOI":"10.1159\/000332368","type":"journal-article","created":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T15:46:54Z","timestamp":1330616814000},"page":"272-276","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility Study on Biweekly Paclitaxel Treatment as Maintenance Chemotherapy in Advanced M\u00fcllerian Carcinoma"],"prefix":"10.1159","volume":"73","author":[{"given":"Yukihisa","family":"Minagawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneaki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Itamochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuminori","family":"Kitada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junzo","family":"Kigawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.02.153"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2909738-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.2001.6552"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-1438.2003.13360.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2004.09.088"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2Fdjj296"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000100987"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2009.04.012"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2009.21.9691"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199504133321507"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2809%2961157-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-8258%2803%2900322-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2011.03.013"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.04.7373"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa0707056"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198212023072302"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:48:52Z","timestamp":1745434132000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000332368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,6,1]]},"published-print":{"date-parts":[[2012,6,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000332368","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2012]]}}}