{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:13:54Z","timestamp":1790802834987,"version":"4.1.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Aims:&lt;\/i&gt; To compare the antianginal efficacy of trimetazidine with that of other agents with no influence on heart rate. &lt;i&gt;Methods and Results:&lt;\/i&gt; Medline and Embase databases were searched for blinded, randomized, controlled trials assessing the effects of non-heart-rate-lowering antianginal treatments on exercise tolerance and\/or clinical criteria in stable angina patients. All relevant trimetazidine trials including the VASCO trial, the results of which are published herein, were included. A Bayesian network meta-analysis on the summary data was performed. Comparator antianginal agents were considered as a group and in agent\/class subgroups. Trials involving \u03b2-blockers, non-dihydropyridine calcium channel blockers, and ivabradine were excluded. 218 trials totaling 19,028 patients were included in at least 1 network analysis. Effects of trimetazidine were statistically significant compared with placebo for exercise tolerance and clinical criteria. Transposition of results into seconds for clinical interpretation of exercise tolerance parameters showed a mean improvement of +46 s (95% credibility interval: 28; 66) for total exercise duration, +55 s (35; 77) for 1-mm ST segment depression (T1), and +54 s (24; 84) for time to onset of angina, in favor of trimetazidine. Differences between trimetazidine and active comparators were not significant when exercise tolerance and clinical criteria were analyzed, with +7 s (\u201312; 28) for total exercise duration, \u20131 s (\u201323; 22) for T1, +8 s (\u201322; 40) for time to onset of angina, and \u20130.28 (\u20131.17; 0.64) attacks per week for trimetazidine compared with antianginal agents as a group. &lt;i&gt;Conclusions:&lt;\/i&gt; Trimetazidine efficacy was comparable to that of other non-heart-rate-lowering antianginal treatments in patients with stable angina pectoris.<\/jats:p>","DOI":"10.1159\/000332369","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T07:42:33Z","timestamp":1322120553000},"page":"59-72","source":"Crossref","is-referenced-by-count":71,"title":["Efficacy Comparison of Trimetazidine with Therapeutic Alternatives in Stable Angina Pectoris: A Network Meta-Analysis"],"prefix":"10.1159","volume":"120","author":[{"given":"Nicolas","family":"Danchin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Marzilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Parkhomenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge P.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,11,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehl001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00051292"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Feuhj.2001.2896"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1152%2Fphysrev.00015.2009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehi816"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00019501-200304000-00010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2174%2F138161209787582075"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2165%2F00129784-200303050-00007"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2165%2F00129784-200505040-00006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2010.208751"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fsim.1875"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1524-4733.2008.00347.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fsim.3767"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.327.7414.557"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2165%2F00044011-199713010-00002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-3928%2802%2900129-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2165%2F00044011-200424120-00004"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2898%2900500-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2165%2F00129784-200202020-00005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2FFJC.0b013e31814fa9cb"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:48:52Z","timestamp":1745434132000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000332369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000332369","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5122900","asserted-by":"subject"}]},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}