{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:07:31Z","timestamp":1780614451247,"version":"3.54.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> High-dose testosterone treatment is a well-known, though still controversial, therapy in boys with tall stature. <i>Methods:<\/i> 161 boys with constitutional tall stature were treated at two different treatment centers (center A 114 patients; center B 47 patients). In center A, boys were treated with 500 mg and in center B with 250 mg testosterone enanthate intramuscularly every 2 weeks. Predicted adult height (PAH) was calculated according to the Bayley\/Pinneau method using the Greulich-Pyle method for bone age determination. <i>Results:<\/i>At onset of treatment, the patients at the two centers did not differ with respect to chronological age (center A 14.2 \u00b1 1.3 years; center B 13.5 \u00b1 1.1 years), height (center A 187.8 \u00b1 7.3 cm; center B 185.5 \u00b1 5.5 cm), bone age (center A 13.8 \u00b1 0.8 years; center B 13.6 \u00b1 0.7 years), or PAH (center A 205.2 \u00b1 5.2 cm; center B 204.8 \u00b1 5.5 cm). Mean treatment duration was significantly longer in center A than in center B (14.2 \u00b1 4.0 vs. 11.3 \u00b1 2.2 months). At the end of the testosterone treatment, PAH did not differ significantly (center A 197.7 \u00b1 5.3 cm; center B 196.1 \u00b1 4.7 cm). The mean reduction in PAH at the end of treatment was 7.6 \u00b1 5.0 cm (center A) and 8.7 \u00b1 5.6 cm (center B) which is \u223c50% of the expected growth at onset of treatment. <i>Conclusions:<\/i> A testosterone enanthate dose of 250 mg every 2 weeks was as effective in reducing adult height in boys with tall stature as a dose of 500 mg every 2 weeks.<\/jats:p>","DOI":"10.1159\/000332735","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T07:36:34Z","timestamp":1318923394000},"page":"343-347","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of Tall Stature in Boys: Comparison of Two Different Treatment Regimens"],"prefix":"10.1159","volume":"76","author":[{"given":"Thomas","family":"Reinehr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Gueldensupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Wunsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen H.","family":"Bramswig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,10,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.81.3.1206"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004310050740"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.02087"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1754.2008.01428.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.06.011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.01880"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00445913"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004310050741"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2852%2980205-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00112-004-0929-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.1988.01670030080027"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2010-0435"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.81.1.296"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1995.tb01897.x"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:51:39Z","timestamp":1745434299000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000332735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,11,1]]},"published-print":{"date-parts":[[2011,11,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000332735","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}