{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:38Z","timestamp":1787017898071,"version":"build-2736575974"},"reference-count":5,"publisher":"S. Karger AG","issue":"1-4","license":[{"start":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T00:00:00Z","timestamp":1324598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T00:00:00Z","timestamp":1324598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Helicobacter pylori&lt;\/i&gt; eradication has a differential effect on the facets of idiopathic parkinsonism (IP): brady\/hypokinesia improves, but rigidity worsens. Small intestinal bacterial overgrowth is common in IP and has been described as a sequel to &lt;i&gt;Helicobacter&lt;\/i&gt; eradication. The hyperhomocysteinaemia of IP is, in part, explained by serum vitamin B&lt;sub&gt;12&lt;\/sub&gt;, but the concentration is not explained by &lt;i&gt;Helicobacter &lt;\/i&gt;status. Moreover, &lt;i&gt;Helicobacter&lt;\/i&gt;-associated gastric atrophy is uncommon in IP. However, overgrowth both increases B&lt;sub&gt;12&lt;\/sub&gt; utilization and provides a source of inflammation to drive homocysteine production. It is not a bystander event in IP: clouds of lysosomes are seen in duodenal enterocytes. Its candidature for causality of a rigidity-associated pathway is circumstantial: there are biological gradients of rigidity on natural killer and T-helper blood counts, both being higher with hydrogen breath test positivity for overgrowth.<\/jats:p>","DOI":"10.1159\/000332807","type":"journal-article","created":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T03:02:55Z","timestamp":1324609375000},"page":"183-186","source":"Crossref","is-referenced-by-count":5,"title":["Towards Defining a Rigidity-Associated Pathogenic Pathway in Idiopathic Parkinsonism"],"prefix":"10.1159","volume":"10","author":[{"given":"R. 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