{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:00:17Z","timestamp":1791115217834,"version":"4.1.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease. Since current treatments are unsatisfactory for many patients, there is a high need for effective drugs for this debilitating disease. Recent pathogenic insights suggest inflammasome activation and IL-1\u03b2 production are important in HS. Colchicine is efficacious in the IL-1\u03b2- and inflammasome-mediated diseases gout, familial Mediterranean fever and Beh\u00e7et\u2019s disease, and therefore a potentially effective drug in HS. &lt;i&gt;Objective:&lt;\/i&gt; To investigate the efficacy of colchicine in HS. &lt;i&gt;Methods:&lt;\/i&gt; In an open prospective pilot study, 8 HS patients were treated with the accepted gout maintenance regimen of 0.5 mg colchicine b.i.d. orally up to 4 months. Efficacy was assessed by a physician global assessment. &lt;i&gt;Results:&lt;\/i&gt; Colchicine treatment did not result in a clinically relevant improvement of disease severity. Three patients experienced nausea and diarrhea as known side effects. &lt;i&gt;Conclusion:&lt;\/i&gt; Colchicine in the used dose regimen does not ameliorate HS severity.<\/jats:p>","DOI":"10.1159\/000332846","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T08:00:33Z","timestamp":1318492833000},"page":"169-173","source":"Crossref","is-referenced-by-count":33,"title":["The Anti-Inflammatory Drug Colchicine Lacks Efficacy in Hidradenitis Suppurativa"],"prefix":"10.1159","volume":"223","author":[{"given":"H.H.","family":"van der Zee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.P.","family":"Prens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,10,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2896%2990321-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2008.06.020"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2006.08.061"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2001.04137.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4362.1983.tb02150.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2898%2970272-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1986.tb05740.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2011.10339.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2009.06.050"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1524-4725.2009.01214.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000228337"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.2009.03377.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2009.12.018"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Frheumatology%2F36.5.602"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2010.10071.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchdermatol.2010.328"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2011.10254.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature04516"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2FGIM.0b013e3182060456"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejim.2010.09.010"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000182257"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jbspin.2006.03.006"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.40.6.605"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1517%2F14656566.2010.529432"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:52:30Z","timestamp":1745434350000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000332846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,11,1]]},"published-print":{"date-parts":[[2011,11,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000332846","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}