{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:15:34Z","timestamp":1760955334960,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2012]]},"abstract":"<i>Background:<\/i> The precision of the methods used to diagnose latex allergy is of great importance due to false-positive results. Neither the skin prick test (SPT) nor the latex-specific IgE assay has 100% diagnostic accuracy. We analysed the diagnostic value of latex-specific IgE by the first-ever concomitant use of the SPT and nasal provocation test (NPT). <i>Methods:<\/i> Twenty-seven latex-sensitive patients (group 1), 46 aeroallergen-sensitive patients (group 2a) and 33 healthy subjects (group 2b) participated in the study. All groups underwent an SPT with latex and aeroallergens and an NPT with latex. Latex-specific IgE and total IgE levels were measured by the ImmunoCAP assay. <i>Results:<\/i> Latex-specific IgE was positive in 92.6, 30.4 and 9.1% of groups 1, 2a and 2b, respectively. The 11 aeroallergen-sensitive patients in group 1 and all of the patients in group 2a were predominantly sensitised to pollens (grass, weed and tree) and reacted to a lesser degree to house dust mite, moulds and animal dander. Combined pollinosis was remarkably more prevalent in patients with positive latex-specific IgE in group 2a than in those with negative latex-specific IgE (p = 0.001). The NPT was positive in 84.6% of group 1 and negative in all control subjects. The sensitivity, specificity, negative predictive value and positive predictive value of the latex-specific IgE assay were 90.9, 72.2, 96.3 and 50%, respectively. <i>Conclusion:<\/i> The high rate of false-positive results for latex-specific IgE by ImmunoCAP should be taken into account when making a diagnosis of latex allergy in patients with pollinosis, especially in those sensitised to more than one pollen species.<\/jats:p>","DOI":"10.1159\/000332929","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T10:49:48Z","timestamp":1331030988000},"page":"281-287","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic Value of Specific IgE Analysis in Latex Allergy"],"prefix":"10.1159","volume":"158","author":[{"given":"Mehmet","family":"\u00dcnsel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"Mete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6m\u00fcr","family":"Ardeniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayt\u00fcl","family":"Sin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okan","family":"G\u00fclbahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Kokuluda\u011f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2007.01347.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2962755-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2008.01651.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2008.01901.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.105219"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.124969"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00130832-200404000-00005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2897%2970249-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.1999.00145.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.1995.tb01051.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000053819"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.00553.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2961830-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11882-010-0128-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2899%2970171-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2004.01837.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/332929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:52:57Z","timestamp":1745434377000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000332929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,6,1]]},"published-print":{"date-parts":[[2012,6,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000332929","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2012]]}}}