{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:18:02Z","timestamp":1760984282747,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2012]]},"abstract":"<i>Objective:<\/i> To investigate the clinical therapeutic outcomes and neck node control of a pretreatment neck dissection in the chemoradiation protocol of organ preservation for N2-N3 of supraglottic and hypopharyngeal carcinoma. <i>Methods:<\/i> Forty-six patients (group A) with untreated N2 or N3 squamous cell carcinoma of the supraglottis or hypopharynx underwent pretreatment neck dissection in a chemoradiation protocol, while 39 patients (group B) did not undergo pretreatment neck dissection in a chemoradiation protocol. Salvage surgeries were used for local or cervical node residual tumor or recurrence after chemoradiotherapy. <i>Results:<\/i> In group A, the mean time between neck dissection and chemoradiation was 21 days (range 15-29). Only 3 patients (6.5%) experienced wound complications. A \u2018boost' of radiation of 12 Gy was delivered after 33 neck dissections (64.8%) in patients with extracapsular spread. The Kaplan-Meier 5-year overall survival rate was 42.5%. The 5-year overall survival rate and disease-specific survival rate in group A was 42.5 and 46.4%. The rate of neck node control in group A was better than that in group B (86.3 vs. 65.9%, p = 0.02). <i>Conclusions<\/i>: Pretreatment neck dissection in a chemoradiation protocol for supraglottic or hypopharyngeal carcinoma showed low complication rates, no delay for radiation, optimal radiation doses, and a high nodal disease control.<\/jats:p>","DOI":"10.1159\/000333111","type":"journal-article","created":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T09:44:21Z","timestamp":1328694261000},"page":"64-69","source":"Crossref","is-referenced-by-count":16,"title":["Planned Neck Dissection before Combined Chemoradiation in Organ Preservation Protocol for N2-N3 of Supraglottic or Hypopharyngeal Carcinoma"],"prefix":"10.1159","volume":"74","author":[{"given":"Xue-Kui","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Xia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong-Yuan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu-Ming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00001622-200205000-00012"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080%2F00016480701477669"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1288%2F00005537-199208000-00015"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0347%28199611%2F12%2918%3A6%3C552%3A%3AAID-HED10%3E3.0.CO%3B2-A"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fhed.10187"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001%2Farchotol.1995.01890020024006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0167-8140%2896%2901880-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Farchotol.1986.03780040077016"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10006-006-0684-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fhed.20372"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080%2F00016480500401019"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijrobp.2008.04.021"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijrobp.2008.02.016"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.radonc.2008.06.011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fhed.10394"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00005537-200011000-00003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fhed.10293"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1017%2FS002221510011000X"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fhed.10374"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001%2Farchotol.130.7.831"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa032641"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/333111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/333111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:55:02Z","timestamp":1745434502000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000333111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,4,1]]},"published-print":{"date-parts":[[2012,4,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000333111","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"type":"print","value":"0301-1569"},{"type":"electronic","value":"1423-0275"}],"subject":[],"published":{"date-parts":[[2012]]}}}