{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:47Z","timestamp":1745469347741,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Insulin resistance (IR) has been reported to be an independent predictor of treatment outcome in chronic hepatitis C patients. &lt;i&gt;Methods:&lt;\/i&gt; We analyzed the relationship between IR and the outcome of pegylated interferon and ribavirin (PEG-IFN\/RBV) therapy, taking into account host factors of body mass index and histological index, such as rate of fatty change and fibrosis. Japanese patients (n = 30; 19 men and 11 women; median age 60.0 \u00b1 8.7 years) with chronic hepatitis C-1b with a high viral load were treated with PEG-IFN-\u03b12b\/RBV for 48 weeks. &lt;i&gt;Results:&lt;\/i&gt; Sustained virological response (SVR) was seen in 60% (18\/30) and non-SVR in 40% (12\/30). HOMA-IR (homeostasis model of assessment-insulin resistance index) at the start and at 24 weeks of treatment showed no statistical difference between SVR and non-SVR. Correlation was observed between HOMA-IR and body mass index (r = 0.45, p = 0.013). Among 20 patients, steatosis and fibrosis were assessed by biopsy. Correlation was observed between HOMA-IR and steatosis (r = 0.57, p = 0.0093), whereas no correlation was observed between HOMA-IR and fibrosis. &lt;i&gt;Conclusion:&lt;\/i&gt; A larger prospective study is needed to clarify the role of IR in the outcome of PEG-IFN\/RBV combination therapy and hepatic fibrosis in Japanese patients.<\/jats:p>","DOI":"10.1159\/000333208","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T09:43:36Z","timestamp":1322905416000},"page":"5-9","source":"Crossref","is-referenced-by-count":2,"title":["Correlation between Insulin Resistance and Outcome of Pegylated Interferon and Ribavirin Therapy, Hepatic Steatosis, Hepatic Fibrosis in Chronic Hepatitis C-1b and High Viral Load"],"prefix":"10.1159","volume":"84","author":[{"given":"Soo 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