{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:03:14Z","timestamp":1787936594492,"version":"build-2784847793"},"reference-count":31,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objective:<\/i> To determine if focal \u2018nuclear atypia\u2019 or \u2018microfollicular architecture\u2019 portends a higher risk of malignancy than other subcategories of atypia of undetermined significance (AUS) in thyroid fine-needle aspirations (FNAs). <i>Study Design:<\/i> The frequencies of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) categories were calculated from 3,956 thyroid FNAs interpreted over a 26-month period at The Johns Hopkins Hospital after adoption of TBSRTC. TBSRTC criteria were applied strictly. The risk of malignancy, specifically for AUS subcategories, was analyzed by cyto-histo correlation. <i>Results:<\/i> Of the 133 cases diagnosed as AUS, 32% were found to have stageable carcinoma (not incidental microcarcinoma) on resection. When the subset of AUS with \u2018nuclear atypia\u2019 (AUS-N) was separated from other AUS cases, 48% (30\/62) of them had stageable carcinoma on resection; of the AUS subset with \u2018microfollicular architecture\u2019 (AUS-F), 27% (8\/30) were malignant on resection. The \u2018suspicious for papillary thyroid carcinoma\u2019 (SPTC) group maintained a higher risk of malignancy versus AUS-N (relative risk, RR 1.57; 95% CI 1.23\u20131.81). <i>Conclusion:<\/i> The subcategory of \u2018nuclear atypia\u2019 within AUS indicates a higher risk of malignancy than other subcategories of AUS but has a lower risk of malignancy than SPTC does. Thus, it is an important distinction with potential clinical implications.<\/jats:p>","DOI":"10.1159\/000333232","type":"journal-article","created":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T08:20:51Z","timestamp":1323418851000},"page":"518-525","source":"Crossref","is-referenced-by-count":138,"title":["Spectrum of Risk of Malignancy in Subcategories of \u2018Atypia of Undetermined Significance\u2019"],"prefix":"10.1159","volume":"55","author":[{"given":"Matthew T.","family":"Olson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas P.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yener S.","family":"Erozan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Z.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002680010175"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2882%2990731-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-1772"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clon.2010.05.004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.295.18.2179"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.24416"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Flary.21076"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.295.18.2164"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.2008.0425"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.23343"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.20830"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186%2F1742-6413-5-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1309%2FAJCPPHLWMI3JV4LA"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.2009.0274"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncy.20029"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000324996"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.21093"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncy.20154"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-200205000-00007"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.21702"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncy.20063"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2010-1087"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.2010.0243"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2808%2970132-3"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2559.2002.01304.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.2008.0108"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1309%2FAJCP5N4MTHPAFXFB"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1309%2FAJCP4P2GCCDNHFMY"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.2009.0155"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncy.20091"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1309%2FAJCP0RW2WMDUAKGK"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/333232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/333232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:55:27Z","timestamp":1745434527000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000333232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000333232","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}