{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:03Z","timestamp":1745469303003,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; We intended to evaluate the association between specific human leukocyte antigen (HLA)-DRB1 gene polymorphism and antiviral response to lamivudine (LAM) therapy in chronic hepatitis B (CHB) patients. &lt;i&gt;Methods:&lt;\/i&gt; Six-digit HLA-DRB1 genotypes were determined using sequence-based typing in 334 CHB patients initially treated with LAM for at least 12 months. Antiviral response was evaluated every 3\u20136 months during LAM therapy. &lt;i&gt;Results:&lt;\/i&gt; Median age of the subjects was 43 years (range, 16\u201372). Median duration of LAM therapy was 69 months (range, 13\u2013140). Median baseline serum hepatitis B virus (HBV DNA) level was 7.0 log&lt;sub&gt;10&lt;\/sub&gt; copies\/ml (range, 5.5\u20139.1). At 12 months of LAM therapy, serum HBV DNA was undetectable by solution hybridization method in 308 (88%) patients. Among 25 HLA-DRB1 alleles identified, HLA-DRB1*090102, *080302, and *070101 were the most frequent alleles (&gt;10%). HLA-DRB1*010101 was identified in 5.4% (18\/334). The frequency of the HLA-DRB1*010101 allele was significantly lower in patients with virological response at 12 months of LAM therapy than in patients without it (4.2 vs. 19.2%, p = 0.025). The other HLA-DRB1 alleles were not associated with virological response. HBeAg loss\/seroconversion and alanine aminotransferase normalization were not associated with HLA-DRB1 alleles. &lt;i&gt;Conclusion:&lt;\/i&gt; The HLA-DRB1*010101 allele is closely associated with poor virological response to initial LAM therapy in CHB patients.<\/jats:p>","DOI":"10.1159\/000333783","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T09:43:36Z","timestamp":1322905416000},"page":"35-42","source":"Crossref","is-referenced-by-count":3,"title":["HLA-DRB1*010101 Allele Is Closely Associated with Poor Virological Response to Lamivudine Therapy in Patients with Chronic Hepatitis B"],"prefix":"10.1159","volume":"84","author":[{"given":"Young-Joo","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju 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