{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:42:19Z","timestamp":1775634139578,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T00:00:00Z","timestamp":1321920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T00:00:00Z","timestamp":1321920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; While topical ocular hypotensive agents cause secretion of endogenous prostaglandin (PG), systemic and topical non-steroidal anti-inflammatory agents inhibit its production; thus, they may interfere with therapeutic efficacy. This study aimed to investigate the effect of add-on treatment with ketorolac on intra-ocular pressure (IOP)-lowering effects of three different PG analogues. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This study included 30 adult bilateral glaucoma patients who had been receiving PG analogues for primary open-angle glaucoma (n = 25) or pseudoexfoliation glaucoma (n = 5). Ketorolac tromethamine 0.5% and placebo drops were administered to the right and left eyes of the patients, respectively, 4 times a day for 1 week. IOP measurements were performed at baseline, within the first 4 h after application, on days 1, 3 and 7, and 1 and 7 days after discontinuation of the treatment. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Eyes receiving ketorolac had significantly lower IOP throughout the treatment period (p &lt; 0.001). Patients who were on latanoprost, travoprost and bimatoprost did not differ with regard to the change in IOP (p = 0.780). After discontinuation, pressures became similar on day 1 (p = 0.796) and day 7 (p = 0.314). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In glaucoma patients, ketorolac significantly enhances the IOP-lowering effects of latanoprost, travoprost and bimatoprost.<\/jats:p>","DOI":"10.1159\/000333822","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T09:15:52Z","timestamp":1321953352000},"page":"205-209","source":"Crossref","is-referenced-by-count":17,"title":["Effect of Ketorolac Add-On Treatment on Intra-Ocular Pressure in Glaucoma Patients Receiving Prostaglandin Analogues"],"prefix":"10.1159","volume":"227","author":[{"given":"Ece","family":"Turan-Vural","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Torun-Acar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suphi","family":"Acar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,11,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2803%2900098-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2007.07.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2005.10.045"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0039-6257%2802%2900327-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2801%2901177-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2005.01.042"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.84.11.1228"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2147%2FOPTH.S15146"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006%2Fexer.1996.0119"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.survophthal.2008.08.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.exer.2005.03.020"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2004.11.062"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2801%2901286-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2005.080895"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.87.3.297"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F02713680802100845"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3129%2Fi10-048"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12325-009-0042-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.06-0100"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-4835%2805%2980123-X"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0039-6257%2802%2900310-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10384-005-0293-x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02850153"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.126.7.914"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.02-0323"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/333822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/333822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:42:10Z","timestamp":1745433730000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000333822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,22]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,1]]},"published-print":{"date-parts":[[2012,4,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000333822","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,22]]}}}