{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:49:57Z","timestamp":1790660997637,"version":"4.1.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T00:00:00Z","timestamp":1323216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T00:00:00Z","timestamp":1323216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To evaluate long-term structural and functional changes of the optic nerve head in medically and surgically treated juvenile-onset primary open-angle glaucoma (JOAG). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Forty-two eyes of 42 consecutive primary JOAG patients presenting between January 2000 and January 2003. Results were analysed for long-term intra-ocular pressure (IOP) control, IOP fluctuation, disc characteristics on a Heidelberg Retinal Tomograph II and for visual field changes over a 5-year period. The parameters were compared between medically and surgically treated eyes. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The average age of the patients was 26.8 \u00b1 6.1 years. The average baseline IOP was 35.3 \u00b1 14.9 mm Hg. An IOP control &lt;18 mm Hg was achieved in 84% of eyes that underwent filtering surgery (n = 17), compared to 63% on medical therapy alone (n = 25) at the end of 5 years; log rank test p = 0.38. Over 5 years, 4 eyes showed progression (9.5%) of which 3 had been medically treated and 1 had failed surgery (p = 0.45). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; A tenth of JOAG eyes showed progression over 5 years, and this was more common in those treated medically. Aggressive IOP lowering may thus be needed in eyes with JOAG.<\/jats:p>","DOI":"10.1159\/000334033","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T07:43:00Z","timestamp":1323243780000},"page":"19-25","source":"Crossref","is-referenced-by-count":26,"title":["Long-Term Structural and Functional Outcomes of Therapy in Juvenile-Onset Primary Open-Angle Glaucoma : A Five-Year Follow-Up"],"prefix":"10.1159","volume":"228","author":[{"given":"Viney","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanjit","family":"Sihota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,12,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000308803"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.1989.03420020103038"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02343067"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000048293"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2005.07.044"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00417-003-0732-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.86.5.551"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9394%2884%2990193-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2802%2901658-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000068250"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00061198-200012000-00004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2802%2901769-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2FIJG.0b013e3181a2fa31"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2005.04.038"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.eye.6701819"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.85.8.956"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ijg.0000133151.82804.e3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2800%2900538-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.121.1.48"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2004.02.017"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.125.8.1010"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:44:09Z","timestamp":1745433849000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,7]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,6,1]]},"published-print":{"date-parts":[[2012,6,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000334033","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,7]]}}}