{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:46:41Z","timestamp":1765079201631,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T00:00:00Z","timestamp":1323993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T00:00:00Z","timestamp":1323993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Recent studies suggest an increased risk for &lt;i&gt;Pneumocystis jirovecii&lt;\/i&gt; pneumonia (PJP) in adults receiving short-interval rituximab-CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) therapy for diffuse large cell B cell lymphoma (DLBCL). This retrospective study evaluates precise PJP incidence and the efficacy of anti-PJP prophylaxis in DLBCL. Patients with DLBCL, aged \u226718 years and treated between December 2004 and December 2010, were included. Details of treatment-related respiratory infections, focusing on PJP incidence, risk factors and prophylaxis, were assessed. A total of 132 patients were analyzed; 47 were treated with rituximab-CHOP therapy every 21 days (R-CHOP-21) and 85 were treated every 14 days (R-CHOP-14). The incidence of treatment-related respiratory infections was higher in patients receiving R-CHOP-14. PJP was diagnosed in 5 patients: 4 in the R-CHOP-14 (6.6%) and 1 in the R-CHOP-21 cohort (2.6%), using triplex polymerase chain reaction (PCR) for PJ in bronchoalveolar fluid. None of the patients receiving &lt;i&gt;P.&lt;\/i&gt;&lt;i&gt;jirovecii&lt;\/i&gt; prophylaxis (n = 33) developed PJP, compared with 6.6% of those treated with R-CHOP-14 without such prophylaxis. An older age and R-CHOP administered every 14 rather than every 21 days increased the PJP risk. Trimethoprim\/sulfamethoxazole prophylaxis is found to be highly efficient in preventing this life-threatening complication and, therefore, should be recommended for patients receiving the R-CHOP-14 regimen.<\/jats:p>","DOI":"10.1159\/000334113","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T08:17:35Z","timestamp":1324023455000},"page":"110-114","source":"Crossref","is-referenced-by-count":30,"title":["The Increased Risk for Pneumocystis Pneumonia in Patients Receiving Rituximab-CHOP-14 Can Be Prevented by the Administration of Trimethoprim\/Sulfamethoxazole: A Single-Center Experience"],"prefix":"10.1159","volume":"127","author":[{"given":"Emilia","family":"Hardak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilana","family":"Oren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldad J.","family":"Dann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mordechai","family":"Yigla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Faibish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob M.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irit","family":"Avivi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2002.03419.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109%2F10428191003699860"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199304083281404"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa011795"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3324%2Fhaematol.10564"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2FMAJ.0b013e318210ff42"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2808%2970002-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0609.2007.00994.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijid.2010.03.025"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Frheumatology%2Fken234"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109%2F10428194.2010.506569"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109%2F10428191003715377"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2217%2Ffmb.09.116"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-1360"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109%2F10428194.2010.525726"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334113","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:44:44Z","timestamp":1745433884000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,16]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000334113","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2011,12,16]]}}}