{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T10:31:04Z","timestamp":1751365864338,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To investigate the effects of topical application of cyclosporine or vitamin A on the ocular surface during the concurrent administration of antiglaucoma drugs. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Thirty rabbits were randomized into 5 groups. Group 1 was administered timolol, group 2 received travoprost, group 3 received a travoprost\/timolol fixed combination solution, group 4 received timolol and travoprost, and group 5 received timolol, travoprost, and dorzolamide. Each group was divided into a subgroup that received only the antiglaucoma medication (subgroup A), a subgroup that received topical cyclosporine in addition to the antiglaucoma medication (subgroup B), and a subgroup that received topical vitamin A in addition to the antiglaucoma medication (subgroup C). Conjunctival impression cytology specimens were collected at baseline and at weeks 1, 3, and 6. Conjunctival biopsy specimens were collected at week 6. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The impression cytologic study results are as follows: statistically significant differences were found between groups 4A and 4B and between groups 4A and 4C at week 6 (p = 0.004, p = 0.006, respectively) and between groups 5A and 5B and between groups 5A and 5C at weeks 3 and 6 (p = 0.006, p = 0.008 at week 3, p = 0.003, p = 0.004 at week 6, respectively). No statistically significant differences were found between subgroup B and subgroup C in any of the groups at any of the times evaluated (p &gt; 0.05). The conjunctival biopsy specimens from groups 1, 2, and 3 showed no distortion, but groups 4A and 5A showed distortion of the conjunctival epithelial structures. Groups 4B, 4C, 5B, and 5C showed less distortion of the conjunctival epithelial structures. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Administration of cyclosporine or vitamin A may reduce the adverse ocular surface changes caused by long-term administration of antiglaucoma drugs.<\/jats:p>","DOI":"10.1159\/000334248","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T08:35:06Z","timestamp":1336552506000},"page":"139-145","source":"Crossref","is-referenced-by-count":8,"title":["The Effect of Additional Topical Cyclosporine or Vitamin A on the Ocular Surface during Antiglaucoma Medication Administration"],"prefix":"10.1159","volume":"48","author":[{"given":"Hyun Kyung","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myoung Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Il","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2802%2901974-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2898%2991133-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1442-9071.2000.00237.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004170100328"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2004.06.023"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2008.08.015"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2006.05.077"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.126.8.1046"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2FICO.0b013e318158f6dc"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchophthalmol.2008.608"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2005.05.013"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000310829"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2005.073916"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1983.01040020871007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1994.01090230060021"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1990.01070130045027"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1005892426045"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1989.01070020345002"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F01.iio.0000212137.85298.98"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:46:12Z","timestamp":1745433972000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000334248","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2012]]}}}