{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:25:14Z","timestamp":1791181514387,"version":"4.1.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T00:00:00Z","timestamp":1321574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T00:00:00Z","timestamp":1321574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Follicular lymphoma (FL) cases with a t(14;18)(q32;q21) and minimal or no additional karyotypic alterations, such as copy number gains and losses and\/or chromosomal rearrangements, may exhibit pathologic features and a clinical behavior similar to those with more complex karyotypes. This study sought to investigate whether the copy-neutral loss of heterozygosity (cnLOH) profiles of these minimally evolved t(14;18)(q32;q21)-positive follicular lymphoma (MEV-FL) cases are similar to or different from the majority of FL cases with more karyotypic alterations. Affymetrix SNP 6.0 array analysis was applied to the tumor genomes of 23 MEV-FL biopsy samples to assess for the presence of cnLOH. These cases carried either a single or no chromosomal abnormality in addition to t(14;18)(q32;q21) as determined by karyotyping. We found that, although these MEV-FL cases had simple karyotypes, they showed very similar cnLOH profiles as compared to cytogenetically complex cases. The most frequent regions affected by cnLOH were 1p (17%), 6p (17%), 12q (13%) and 16p (13%). Our study suggests that cnLOH alterations may serve as important contributors to the pathological and clinical manifestations of FL.<\/jats:p>","DOI":"10.1159\/000334265","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T07:46:48Z","timestamp":1321861608000},"page":"38-43","source":"Crossref","is-referenced-by-count":10,"title":["SNP Analysis of Minimally Evolved t(14;18)(q32;q21)-Positive Follicular Lymphomas Reveals a Common Copy-Neutral Loss of Heterozygosity Pattern"],"prefix":"10.1159","volume":"136","author":[{"given":"K.J.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rogic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ben-Neriah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Connors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.D.","family":"Gascoyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.E.","family":"Horsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404426"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2008-02-140616"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.20780"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fnar%2Fgkm076"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404696"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.1103"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.20606"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2008-09-177469"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2F349254a0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2889%2990174-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2008-08-174953"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-07-0456"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3324%2Fhaematol.12232"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:46:24Z","timestamp":1745433984000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,18]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,1]]},"published-print":{"date-parts":[[2012,1,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000334265","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"value":"1424-8581","type":"print"},{"value":"1424-859X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,18]]}}}