{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:23:00Z","timestamp":1790266980526,"version":"4.1.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"1-4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Neuropathological studies supported by experimental animal studies show that the constituents of the innate immunity are intimately involved in the early steps of the pathological cascade of Alzheimer\u2019s disease (AD). &lt;i&gt;Objectives:&lt;\/i&gt; To show the evidence that constituents of the innate immunity contribute to the etiology of late-onset AD. &lt;i&gt;Methods:&lt;\/i&gt; Evaluation of the relationship between the constituents of the innate immunity and genetic risk factors for late-onset AD. &lt;i&gt;Results:&lt;\/i&gt; Complement activation and activated microglia are early neuropathogical events in AD brains. Genome-wide association studies have demonstrated gene loci that are linked to the complement system. The production capacity for inflammatory cytokines is under genetic control and the offspring with a parental history of late-onset AD have a higher production capacity for inflammatory cytokines. &lt;i&gt;Conclusion:&lt;\/i&gt; Epidemiological and genetic data suggest that the innate immunity is involved in the etiology of late-onset AD.<\/jats:p>","DOI":"10.1159\/000334287","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T15:23:42Z","timestamp":1326813822000},"page":"271-273","source":"Crossref","is-referenced-by-count":26,"title":["Innate Immunity and the Etiology of Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"10","author":[{"given":"Piet","family":"Eikelenboom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"van Exel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Veerhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke J.M.","family":"Rozemuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem A.","family":"van Gool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen J.M.","family":"Hoozemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2801%2905625-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000073620.42047.D7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2FNEN.0b013e318177eaf4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F1055-8330%2895%2990018-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fng.439"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2990.2011.01181.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000110455"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.gene.6364162"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10875-009-9297-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchgenpsychiatry.2009.146"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000263217.36439.da"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.0b013e3181b6bb95"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:46:34Z","timestamp":1745433994000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":12,"journal-issue":{"issue":"1-4","published-online":{"date-parts":[[2012,4,1]]},"published-print":{"date-parts":[[2012,4,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000334287","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}