{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:24Z","timestamp":1745469324102,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2012]]},"abstract":"<b><i>Background:<\/i><\/b> Hypoxemia in acute lung injury\/acute respiratory distress syndrome (ALI\/ARDS) patients represents a common finding in the intensive care unit (ICU) and frequently does not respond to standard ventilatory techniques. <b><i>Objective:<\/i><\/b> To study whether the early short-term application of high-frequency percussive ventilation (HFPV) can improve gas exchange in hypoxemic patients with ALI\/ARDS or many other conditions in comparison to conventional ventilation (CV) using the same mean airway pressure (P<sub>aw<\/sub>), representing the main determinant of oxygenation and hemodynamics, irrespective of the mode of ventilation. <b><i>Methods:<\/i><\/b> Thirty-five patients not responding to CV were studied. During the first 12 h after admission to the ICU the patients underwent CV. Thereafter HFPV was applied for 12 h with P<sub>aw<\/sub> kept constant. They were then returned to CV. Gas exchange was measured at: 12 h after admission, every 4 h during the HFPV trial, 1 h after the end of HFPV, and 12 h after HFPV. Thirty-five matched patients ventilated with CV served as the control group (CTRL). <b><i>Results:<\/i><\/b> Pa<smlcap>o<\/smlcap><sub>2<\/sub>\/Fi<smlcap>o<\/smlcap><sub>2<\/sub> and the arterial alveolar ratio (a\/A P<smlcap>o<\/smlcap><sub>2<\/sub>) increased during HFPV treatment and a Pa<smlcap>o<\/smlcap><sub>2<\/sub>\/Fi<smlcap>o<\/smlcap><sub>2<\/sub> steady state was reached during the last 12 h of CV, whereas both did not change in CTRL. Pa<smlcap>c<\/smlcap><smlcap>o<\/smlcap><sub>2<\/sub> decreased during the first 4 h of HFPV, but thereafter it remained unaltered; Pa<smlcap>c<\/smlcap><smlcap>o<\/smlcap><sub>2<\/sub> did not vary in CTRL. Respiratory system compliance increased after HFPV. <b><i>Conclusions:<\/i><\/b> HFPV improved gas exchange in patients who did not respond to conventional treatment. This improvement remained unaltered until 12 h after the end of HFPV.<\/jats:p>","DOI":"10.1159\/000334403","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T09:35:07Z","timestamp":1325064907000},"page":"369-376","source":"Crossref","is-referenced-by-count":15,"title":["Early Short-Term Application of High-Frequency Percussive Ventilation Improves Gas Exchange in Hypoxemic Patients"],"prefix":"10.1159","volume":"84","author":[{"given":"Umberto","family":"Lucangelo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter A.","family":"Zin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Fontanesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Antonaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Peratoner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Ferluga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Marras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Borelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Ciccolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Berlot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1097%2F01.CCM.0000150652.91411.66"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1164%2Frccm.200802-335OC"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1007%2Fs001340050783"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1159%2F000101478"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1007%2Fs001340050453"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1001%2Fjama.292.19.2379"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1097%2F00003246-199211000-00020"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1097%2F00005373-198703000-00002"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1097%2F00063198-199705000-00007"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1016%2FS0305-4179%2802%2900051-7"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1016%2Fj.jcrc.2006.03.008"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1097%2FCCM.0b013e31819ef9e1"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1159%2F000111818"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1097%2FCCM.0b013e3181cd0f87"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016%2Fj.resp.2004.04.005"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1016%2FS0022-3476%2879%2980372-8"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1097%2F00003246-198004000-00083"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1378%2Fchest.86.1.30"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1097%2F01.TA.0000135159.94744.5F"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1378%2Fchest.116.2.440"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1016%2Fj.amjsurg.2006.01.021"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1097%2F00005373-198809000-00010"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1007%2Fs00134-007-0848-z"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1007%2Fs00134-010-1993-3"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:47:52Z","timestamp":1745434072000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,28]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,10,1]]},"published-print":{"date-parts":[[2012,10,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000334403","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2011,12,28]]}}}