{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:07:54Z","timestamp":1776319674969,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Doubly committed ventricular septal defect (dcVSD) is the least common type of VSD. Because published studies are rather scarce, this study aimed at evaluating the midterm outcome of dcVSDs. &lt;i&gt;Methods:&lt;\/i&gt; The records of all patients registered in the database of Paediatric and Congenital Cardiology, University Hospitals Leuven, with a dcVSD at 16 years of age were reviewed. Clinical, electrocardiographic and transthoracic echocardiographic changes from baseline, defined as of the age of 16 years, until the latest follow-up were compared. &lt;i&gt;Results:&lt;\/i&gt; Thirty-three patients (20 males, median age 26 years, interquartile range 12) were followed for a median time of 7.9 years (interquartile range 9.8, time range 2\u201325.9). No deaths occurred. In 15 patients (45%), the defect remained patent at baseline. During follow-up, two spontaneous closures (13%) occurred. Eighteen patients (55%) required closure before the age of 16 years. Five (28%) needed reoperation. In the dcVSD closure group, left ventricular ejection fraction decreased from 69 \u00b1 12 to 61 \u00b1 6% (p = 0.028). No significant changes in pulmonary arterial hypertension were noticed. &lt;i&gt;Conclusions:&lt;\/i&gt; Patients with persistently patent dcVSD remained nearly event free during follow-up. Event-free survival after dcVSD closure was markedly lower. These patients developed reduced left ventricular function and had a high risk of reintervention.<\/jats:p>","DOI":"10.1159\/000334427","type":"journal-article","created":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T08:02:45Z","timestamp":1324627365000},"page":"149-156","source":"Crossref","is-referenced-by-count":8,"title":["Doubly Committed Ventricular Septal Defect: Single-Centre Experience and Midterm Follow-Up"],"prefix":"10.1159","volume":"120","author":[{"given":"Charlien","family":"Gabriels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Gewillig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Meyns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"Troost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Van De Bruaene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Van Damme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Budts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,12,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2008.10.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01747853"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.33.2.238"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2009.09.047"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F14017438809106066"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2899%2900594-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00246-002-1345-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.athoracsur.2009.10.057"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.athoracsur.2010.06.022"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.athoracsur.2006.04.030"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2888%2980023-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-4975%2801%2903393-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2800%2901009-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177%2F000331979905000307"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334427","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:48:17Z","timestamp":1745434097000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,1,1]]},"published-print":{"date-parts":[[2012,1,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000334427","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}