{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:46:28Z","timestamp":1790934388832,"version":"4.1.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objective:<\/i> This study reports the efficacy and safety of zoledronic acid (ZOL) in preventing bone loss in postmenopausal patients receiving an aromatase inhibitor (AI) following tamoxifen. <i>Methods:<\/i> Postmenopausal patients with stage I\u2013III hormone receptor-positive breast cancer who received tamoxifen for 2.5\u20133 years were randomized to receive letrozole (2.5 mg\/day) with (n = 47) or without (n = 43) ZOL (4 mg i.v. every 6 months) for 2 years. The primary endpoint was percent change from baseline in lumbar spine (LS) bone mineral density (BMD) up to 60 months. <i>Results:<\/i> Ninety patients (86 evaluable) with a median age of 59 years (42.9\u201383.6), 50\/86 of whom had previously been treated with chemotherapy, were followed for a median time of 41.4 months. While the control group showed a significant decrease in LS T-score (p = 0.0005), the ZOL group presented an increase over time (p = 0.0143). Change over time in LS T-score was significantly different between groups, favoring ZOL (p < 0.0001 at 24 and 48 months). No fractures, renal dysfunction or osteonecrosis of the jaw were reported. The toxicity profile was similar to those previously reported for each drug. <i>Conclusion:<\/i> The addition of ZOL to letrozole was safe and efficacious in maintaining LS BMD in postmenopausal patients with hormone receptor-positive breast cancer and who were receiving letrozole following 2.5\u20133 years of tamoxifen.<\/jats:p>","DOI":"10.1159\/000334456","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T08:24:07Z","timestamp":1323332647000},"page":"298-305","source":"Crossref","is-referenced-by-count":24,"title":["The Protective Effect of Zoledronic Acid on Bone Loss in Postmenopausal Women with Early Breast Cancer Treated with Sequential Tamoxifen and Letrozole: A Prospective, Randomized, Phase II Trial"],"prefix":"10.1159","volume":"81","author":[{"given":"Tamar","family":"Safra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinat","family":"Bernstein-Molho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Pelles-Avraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Stephansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sarid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe J.","family":"Inbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salomon M.","family":"Stemmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Geffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdq159"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2810%2970257-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2967059-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2960200-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2007.11.0726"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2807%2970003-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.05.4882"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2974803-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2007.11.6798"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2808%2970204-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1385%2FMO%3A21%3A2%3A117"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3322%2Fcaac.20103"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080%2F028418698430007"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa0806285"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdq541"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10549-010-1121-7"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334456","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:48:30Z","timestamp":1745434110000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":16,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000334456","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}