{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:24:48Z","timestamp":1761863088533,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; There are still uncertainties regarding the use of whole and parotid ductal saliva as indicators of chronic exposure to fluoride. This study evaluated the effect of water fluoride concentration, age, gender, geographical area and localization (urban\/rural) on fluoride concentrations in whole and ductal saliva. &lt;i&gt;Methods:&lt;\/i&gt; Subjects (n = 300) aged 3\u20137, 14\u201320, 30\u201340 and 50\u201360 years, from five communities (A\u2013E) with different fluoride concentrations in the drinking water, participated in the study. Two samples of drinking water and parotid and whole saliva were collected for each subject and were analyzed for fluoride using appropriate electrode techniques. &lt;i&gt;Results:&lt;\/i&gt; Mean water F concentrations (\u00b1SE, mg\/l, n = 60) were 0.09 \u00b1 0.01, 0.15 \u00b1 0.01, 0.66 \u00b1 0.01, 0.72 \u00b1 0.02, and 1.68 \u00b1 0.08 for A\u2013E, respectively. Mean F concentrations (\u00b1SE, mg\/l, n = 15) ranged between 0.014 \u00b1 0.002 (A, 3\u20137 years) and 0.297 \u00b1 0.057 (D, 14\u201320 years) for whole saliva and 0.009 \u00b1 0.001 (C, 30\u201340 years) and 0.284 \u00b1 0.038 (E, 50\u201360 years) for parotid saliva. Results of multivariate linear regression analysis showed that geographical area and water fluoride concentration exerted the strongest influence in whole and ductal saliva F concentrations, respectively. &lt;i&gt;Conclusion:&lt;\/i&gt; Therefore, parotid ductal saliva seems to be a more appropriate biomarker of fluoride exposure, and factors like age and localization should also be considered when using this biomarker.<\/jats:p>","DOI":"10.1159\/000334479","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T09:43:36Z","timestamp":1322905416000},"page":"568-573","source":"Crossref","is-referenced-by-count":4,"title":["Factors Associated with Fluoride Concentrations in Whole and Parotid Ductal Saliva"],"prefix":"10.1159","volume":"45","author":[{"given":"R.","family":"Fukushima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.","family":"Pessan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.C.","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.R.","family":"Buzalaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177%2F154411130201300206"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1875-595X.2000.tb00552.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177%2F154405910508401208"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0528.2007.00328.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02012789"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1289%2Fehp.7077"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000211718"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000261185"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000261237"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000086842"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0039-9140%2868%2980097-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-9969%2899%2900083-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000113987"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334479","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:48:34Z","timestamp":1745434114000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000334479","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"type":"print","value":"0008-6568"},{"type":"electronic","value":"1421-976X"}],"subject":[],"published":{"date-parts":[[2011]]}}}