{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:11:56Z","timestamp":1791893516038,"version":"4.3.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T00:00:00Z","timestamp":1323993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T00:00:00Z","timestamp":1323993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2012]]},"abstract":"<i>Objective:<\/i> To assess highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) as inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism (PHPT). <i>Materials and Methods:<\/i> A total of 26 patients with asymptomatic PHPT and 22 age- and sex-matched individuals as a control group were recruited for the study. Corrected serum calcium, phosphorus, alkaline phosphatase, serum 25-hydroxyvitamin D, intact parathyroid hormone (PTH), hs-CRP and IL-6 were measured for all subjects. <i>Results:<\/i> Serum hs-CRP and IL-6 were significantly higher in asymptomatic PHPT patients than in the control group (hs-CRP: 4.15 \u00b1 0.54 vs. 2.24 \u00b1 0.11 mg\/l; IL-6: 4.50 \u00b1 0.80 vs. 2.56\u00b1 0.29 pg\/ml; p < 0.001). Moreover, in asymptomatic PHPT patients, serum PTH was significantly correlated with hs-CRP and IL-6 (r = 0.820, p < 0.001 and r = 0.787, p < 0.001, respectively). <i>Conclusion:<\/i> Inflammatory biomarkers were higher in patients with asymptomatic PHPT than in controls. Moreover, serum PTH was significantly correlated with inflammatory biomarkers which may suggest a subclinical inflammatory response in this group of patients.<\/jats:p>","DOI":"10.1159\/000334588","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T07:46:27Z","timestamp":1334735187000},"page":"249-253","source":"Crossref","is-referenced-by-count":25,"title":["Inflammatory Biomarkers in Patients with Asymptomatic Primary Hyperparathyroidism"],"prefix":"10.1159","volume":"21","author":[{"given":"Ahmed Alsayed","family":"Emam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabela Gomaa","family":"Mousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karema Yousif","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel A.","family":"Al-Azab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fpgmj.72.848.323"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2008-1763"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000251503.35795.4f"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000079526"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000033116.22237.F9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2001-011814"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2249.2004.02419.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.81.10.3450"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2005.02363.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fejechocard%2Fjep007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2362.1998.00289.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2006.05.033"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2008.108886"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2174%2F138161209788186290"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199902113400607"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2249.2004.02419.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.142.9.3850"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.140.10.4683"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000168620"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.133.2.617"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.138.7.2665"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.137.10.4285"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:49:06Z","timestamp":1745434146000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,16]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,4,1]]},"published-print":{"date-parts":[[2012,4,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000334588","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,16]]}}}