{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:38:42Z","timestamp":1767969522507,"version":"3.49.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,12,24]],"date-time":"2011-12-24T00:00:00Z","timestamp":1324684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,12,24]],"date-time":"2011-12-24T00:00:00Z","timestamp":1324684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; High levels of cytokines in juvenile idiopathic arthritis (JIA) can alter target cell sensitivity to growth hormone (GH) leading to short stature in adulthood. We hypothesized that the down-regulation of GH receptor (GHR) gene expression could be involved in growth failure of children with JIA. &lt;i&gt;Methods:&lt;\/i&gt; In 18 (12 F and 6 M) prepubertal JIA patients and 13 age- and sex-matched healthy children, we evaluated serum growth-promoting factors and inflammatory indexes. We also measured GHR gene expression, by real-time PCR, in lymphocytes of patients and controls. All parameters were evaluated in patients before and after treatment of JIA. &lt;i&gt;Results:&lt;\/i&gt; The most interesting (p = 0.007) result was the increase in GHR mRNA expression in all JIA patients. Moreover, we observed a significant (p = 0.0156) decrease in IL-6 levels in JIA patients after 2 years of therapy (19.37 \u00b1 41.01) with respect to basal values (90.84 \u00b1 124.71). On the contrary, IGF-I significantly (p = 0.0005) increased to a mean SDS value of 0 (range -1.69 to +1.70 SDS) with respect to values at disease onset (-0.64 SDS). &lt;i&gt;Conclusions:&lt;\/i&gt; Our preliminary data suggest that the restoration of both GHR gene expression and IGF-I secretion correlate with inactive disease in JIA children.<\/jats:p>","DOI":"10.1159\/000334646","type":"journal-article","created":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T08:27:57Z","timestamp":1324974477000},"page":"52-58","source":"Crossref","is-referenced-by-count":9,"title":["Changes in Growth Hormone Receptor Gene Expression during Therapy in Children with Juvenile Idiopathic Arthritis"],"prefix":"10.1159","volume":"77","author":[{"given":"Elena","family":"Bozzola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Meazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Cortis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Lisini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamilia","family":"Laarej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Bozzola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,12,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1999.tb00032.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3899%2Fjrheum.080199"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ghir.2008.01.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1157%2F13048095"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fme.2005-0170"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs100670200098"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000228902"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yexcr.2011.02.017"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.12.5737"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2007-0544"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0105-2896.2005.00338.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.187.4.461"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2F1529-0131%28199908%2942%3A8%3C1635%3A%3AAID-ANR11%3E3.0.CO%3B2-Q"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2F1529-0131%28199812%2941%3A12%3C2117%3A%3AAID-ART6%3E3.0.CO%3B2-P"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.50.9.602"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000229758"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ghir.2008.12.001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2003.07.003"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.3.927"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.140.7.3203"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:49:38Z","timestamp":1745434178000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,24]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000334646","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,24]]}}}