{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:12:24Z","timestamp":1785186744737,"version":"3.55.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Achieving a major molecular response (MMR) is an important predictor of progression-free survival in chronic myeloid leukemia patients treated with imatinib. This requires accurate measurement of &lt;i&gt;BCR-ABL1&lt;\/i&gt; transcripts normalized to a control gene, as well as defining a level (&lt;i&gt;BCR-ABL1&lt;\/i&gt;\/control gene ratio) that will correlate with sustained clinical response. To make these measurements comparable between laboratories, an international scale (IS) is necessary. A &lt;i&gt;BCR-ABL1&lt;\/i&gt;\/control gene ratio of 0.10% represents MMR in the IS. In collaboration with an international reference laboratory in Adelaide, S.A., Australia, we have established and validated a lab-specific conversion factor for expressing &lt;i&gt;BCR-ABL1&lt;\/i&gt; transcript levels in the IS. In this report, we explain the process and steps involved in obtaining a valid lab-specific conversion factor for expressing &lt;i&gt;BCR-ABL1&lt;\/i&gt; transcript levels in the IS.<\/jats:p>","DOI":"10.1159\/000334716","type":"journal-article","created":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T08:07:10Z","timestamp":1326355630000},"page":"135-142","source":"Crossref","is-referenced-by-count":6,"title":["International Reporting Scale of &lt;i&gt;BCR-ABL1&lt;\/i&gt; Fusion Transcript in Chronic Myeloid Leukemia: First Report from India"],"prefix":"10.1159","volume":"127","author":[{"given":"Poonkuzhali","family":"Balasubramanian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezhilarasi","family":"Chendamarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetha","family":"Markose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Branford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biju","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Mathews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mammen","family":"Chandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-01-0092"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fleu.2009.168"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa030513"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2010-03-273979"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-02-005686"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2008-04-150680"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3324%2Fhaematol.12588"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2403135"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj%2Fleu%2F2401592"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3324%2Fhaematol.2010.032979"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182%2Fasheducation-2006.1.211"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.1999.01749.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2886%2990837-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2010-06-291641"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334716","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:50:13Z","timestamp":1745434213000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,1]]},"published-print":{"date-parts":[[2012,3,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000334716","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5123104","asserted-by":"subject"}]},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}