{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:51:39Z","timestamp":1775508699884,"version":"3.50.1"},"reference-count":9,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<i>Background:<\/i> Conventional mechanical ventilator (CMV) breaths during high-frequency jet ventilation (HFJV) are advocated to recruit and stabilize alveoli. <i>Objectives:<\/i> To establish if CMV breath duration delivered during HFJV influences gas exchange, lung mechanics and lung injury. <i>Methods:<\/i> Preterm lambs at 128 days gestational age were studied. HFJV (7 Hz, PEEP 8 cm H<sub>2<\/sub>O, PIP<sub>HFJV<\/sub> 40 cm H<sub>2<\/sub>O, FiO<sub>2<\/sub> 0.4) with superimposed CMV breaths (PIP<sub>CMV<\/sub> 25 cm H<sub>2<\/sub>O, rate 5 breaths\/min) was commenced after delivery and continued for 2 h. CMV breath inspiratory time (<i>t<\/i><sub>I<\/sub>) was either 0.5 s (HFJV+CMV<sub>0.5<\/sub>; n = 8) or 2.0 s (HFJV+CMV<sub>2.0<\/sub>; n = 8). Age-matched unventilated controls (UVC) were included for comparison. <i>Results:<\/i> Serial arterial blood gas analyses were performed. PIP<sub>HFJV<\/sub> was adjusted to target a <i>P<\/i>aCO<sub>2<\/sub> of 45\u201355 mm Hg. FiO<sub>2<\/sub> was adjusted to target SpO<sub>2<\/sub> 90\u201395%. Pressure-volume curves, broncho-alveolar lavage (BAL) and lung tissue samples were obtained postmortem. Gas exchange, ventilation parameters, static lung compliance and BAL inflammatory markers were not different between HFJV+CMV<sub>0.5<\/sub> and HFJV+CMV<sub>2.0<\/sub>. Both ventilation groups had higher BAL inflammatory markers and increased iNOS-positive cells on histology compared to UVC, whilst lung tissue IL-1\u03b2 and IL-6 mRNA expression was higher in the HFJV+CMV<sub>2.0<\/sub> group compared to the UVC group. <i>Conclusions:<\/i> Preterm lambs were ventilated effectively with HFJV and 5 CMV breaths\/min. CMV breath duration did not alter blood gas exchange, ventilation parameters, ex vivo static lung mechanics or markers of lung injury over a 2-hour study, although consistent trends towards increased inflammatory markers with the longer <i>t<\/i><sub>I<\/sub> suggest greater risk of injury.<\/jats:p>","DOI":"10.1159\/000334828","type":"journal-article","created":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T11:19:15Z","timestamp":1326712755000},"page":"267-273","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Conventional Breath Inspiratory Time during High-Frequency Jet Ventilation in Preterm Lambs"],"prefix":"10.1159","volume":"101","author":[{"given":"Gabrielle C.","family":"Musk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme R.","family":"Polglase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Jane","family":"Pillow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.100.4.593"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0095-5108%2805%2970108-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006%2Fmeth.2001.1262"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F01.PCC.0000113263.93347.F1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203%2FPDR.0b013e31820bbdf5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2004.068544"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186%2F1465-9921-10-19"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542%2Fneo.7-2-e95"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pcl.2008.02.016"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/334828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:51:33Z","timestamp":1745434293000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000334828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,6,1]]},"published-print":{"date-parts":[[2012,5,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000334828","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}