{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:35:11Z","timestamp":1780104911834,"version":"3.54.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2012]]},"abstract":"<i>Background:<\/i> Whether hypercholesterolemia is a risk factor for contrast-induced acute kidney injury (CI-AKI) remains unclear. In the present study, the effects of short- and long-term dietary hypercholesterolemia on contrast media-induced nephrotoxicity were evaluated. <i>Methods:<\/i> Rats were fed either a normal rodent diet (N) or high-cholesterol diet (H). At the end of 2 and 8 weeks, 8 rats from each diet group were given a tail vein injection of either iohexol (group NC and group HC) or vehicle (group N and group H). Blood lipids, renal function and renal hemodynamics were evaluated 1 day after contrast media administration. Renal and urinary prostaglandin E<sub>2<\/sub> (PGE<sub>2<\/sub>) and thromboxane B<sub>2<\/sub> (TXB<sub>2<\/sub>) were detected by radioimmunoassay. Renal nitric oxide and malondialdehyde (MDA) were measured by the Griess reaction and thiobarbituric acid method, respectively.<i> Results:<\/i> Contrast media administration increased serum creatinine levels and induced severe renal tubular necrosis in rats fed the high-cholesterol diet for 8 weeks but not in rats fed the normal diet or high-cholesterol diet for 2 weeks. The renal and urinary PGE<sub>2<\/sub> and TXB<sub>2<\/sub> levels increased significantly in rats in group H and group HC at the end of 8 weeks. Renal nitric oxide production decreased, and MDA levels increased markedly in group HC and group H at the end of 8 weeks. <i>Conclusions:<\/i> We conclude that long-term hypercholesterolemia appeared to be a risk factor for CI-AKI, which might be associated with disorders in intrarenal prostaglandins and abnormalities in renal nitric oxide system induced by lipid peroxidation.<\/jats:p>","DOI":"10.1159\/000335077","type":"journal-article","created":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T10:42:56Z","timestamp":1324464176000},"page":"80-89","source":"Crossref","is-referenced-by-count":22,"title":["Effects of Short- and Long-Term Hypercholesterolemia on Contrast-Induced Acute Kidney Injury"],"prefix":"10.1159","volume":"35","author":[{"given":"Dingwei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2011,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2F978-0-387-85998-9_33"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2214%2FAJR.06.1170"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI114895"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2898%2900319-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfl213"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1583%2F1545-1550%282001%29008%3C0609%3APRFABA%3E2.0.CO%3B2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1503%2Fcmaj.1040847"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1998.00906.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1139%2Fy00-012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2800%2900462-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1148%2Fradiol.2422060245"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F01.rli.0000113776.87762.49"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199007053230106"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0720-048X%2896%2901085-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.109.863159"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2803%2900021-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M109546200"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:53:25Z","timestamp":1745434405000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000335077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,21]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,1]]},"published-print":{"date-parts":[[2012,1,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000335077","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,21]]}}}