{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:31:18Z","timestamp":1790685078743,"version":"4.1.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Dermatophytes are the main cause of onychomycosis, but various non-dermatophyte moulds (NDMs) are often the infectious agents in abnormal nails. In particular, &lt;i&gt;Fusarium&lt;\/i&gt; spp. and other NDMs are mostly insensitive to standard onychomycosis treatment with topical agents as well as with oral terbinafine and itraconazole. &lt;i&gt;Objective:&lt;\/i&gt; The aim of this work is to report the efficacy of a topical amphotericin B solution on NDM onychomycosis in a series of 8 patients resistant to multiple conventional topical and systemic treatments. &lt;i&gt;Methods:&lt;\/i&gt; Treatment consisted in the application of an optimized amphotericin B solution once daily to the affected nails and surrounding tissue. No mechanical debridement or medications were allowed except for trimming excessively long nails or in some cases occasionally applying urea-based cream to soften thickened nail plates. &lt;i&gt;Results:&lt;\/i&gt; Onychomycosis was clinically cured in all patients after a 12-month treatment. Mycological cure was obtained in all but 1 patient. &lt;i&gt;Conclusions:&lt;\/i&gt; Topical amphotericin B is an efficacious, safe, cheap and easy-to-apply treatment which should be considered as first-line therapy for NDM onychomycosis.<\/jats:p>","DOI":"10.1159\/000335093","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T09:03:05Z","timestamp":1326186185000},"page":"289-292","source":"Crossref","is-referenced-by-count":54,"title":["Efficacious Treatment of Non-Dermatophyte Mould Onychomycosis with Topical Amphotericin B"],"prefix":"10.1159","volume":"223","author":[{"given":"Massimo","family":"Lurati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Baudraz-Rosselet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Vernez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Spring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olympia","family":"Bontems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Fratti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Monod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clindermatol.2009.12.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clindermatol.2009.12.009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2007.03120.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1590%2FS0037-86822007000500022"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs102270000019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000277762"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000248356"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1099%2Fjmm.0.46723-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2009.09291.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1517%2F13543780902810352"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2001.04378.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.125.6.789"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2174%2F138920009788898019"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijpharm.2009.11.019"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1517%2F17425240802497218"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335093","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:53:30Z","timestamp":1745434410000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000335093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,3,1]]},"published-print":{"date-parts":[[2012,3,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000335093","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}