{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:43:25Z","timestamp":1775576605027,"version":"3.50.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; The aim of this study was to assess the expression and production of inflammation mediators in basal condition and after angiotensin II (AngII) in otosclerosis. &lt;i&gt;Materials and Methods:&lt;\/i&gt; Human stapedial cell cultures (6 otosclerosis and 6 controls) were incubated with AngII (10&lt;sup&gt;\u20137&lt;\/sup&gt;&lt;i&gt;M&lt;\/i&gt;, 24 h) or vehicle. Cytokines and their mRNA expression were assessed by antibody and cDNA arrays. &lt;i&gt;Results:&lt;\/i&gt; In basal conditions, otosclerotic cultures produced higher amounts of interleukin (IL)-1\u03b2 and interferon-inducible protein 10, and smaller amounts of tissue inhibitor of metalloproteinase 2. AngII promoted inflammation by increasing interferon \u03b3 and IL-10, and by decreasing macrophage inflammatory protein 1\u03b1 and soluble tumor necrosis factor receptor II. &lt;i&gt;Conclusions:&lt;\/i&gt; Otosclerotic cultures produced higher proinflammatory cytokines in basal condition. AngII appeared to promote inflammation via these mediators in otosclerosis.<\/jats:p>","DOI":"10.1159\/000335098","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T09:54:04Z","timestamp":1327485244000},"page":"169-178","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Angiotensin II on Inflammation Pathways in Human Primary Bone Cell Cultures in Otosclerosis"],"prefix":"10.1159","volume":"17","author":[{"given":"Milan","family":"Rudi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidija","family":"Milkovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neven","family":"\u017darkovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Sterkers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Ferrary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Bozorg Grayeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,1,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.081006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006%2Fabio.1987.9999"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fcbf.290110406"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.peptides.2006.08.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2FMAO.0b013e318164d12c"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrrheum.2010.196"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4652%28199804%29175%3A1%3C89%3A%3AAID-JCP10%3E3.0.CO%3B2-J"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2801%2900237-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1991.tb19621.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2273.2003.00675.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.19.1.683"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS1074-7613%2800%2900020-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1189%2Fjlb.0603252"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.168.6.2251"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.heares.2010.02.006"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00405-009-0967-y"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:53:32Z","timestamp":1745434412000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000335098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,4,1]]},"published-print":{"date-parts":[[2012,4,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000335098","archive":["Portico"],"relation":{},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"value":"1420-3030","type":"print"},{"value":"1421-9700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}